Howard Hu M.D., M.P.H., Sc.D.
- Email Address(es)
- Office Address
- Health Sciences Building 155 College Street, 6th Floor Toronto, Ontario M5T 3M7
- , Toronto Environmental Molecular Epidemiology Research Group
- Curriculum Vitae
- Clinical Public Health Division
Occupational & Environmental Health Division
Office of Global Public Health Education & Training
- SGS Status
- Full Member
- Appointment Status
- 1. Environmental and molecular epidemiologic research related to heavy metals, potential endocrine disruptors, other neurotoxicants, carcinogens, etc.
- 2. Gene-environment interactions; epigenetic dysregulation
- 3. Fetal/early life exposures and long-term effects
- 4. Aging-environment interactions
- 5. Environmental health, health inequities and health disparities, human rights
- 6. Health and the global environment
- 7. “Big Data” for population health
- 8. Environmental sensitivities/Multiple chemical sensitivities
Education & Training History
9/1973-6/1976 Biology B.Sc. Brown University
9/1977-6/1982 Medicine M.D. Albert Einstein College of Medicine
9/1979-6/1980 (degree in 6/1982*) M.P.H. (Occ Hlth) Harvard School of Public Health
9/1985-6/1986 Epidemiology M.S. Harvard School of Public Health
7/1986-6/1990 Epidemiology Sc.D. Harvard School of Public Health
* Awarding of the M.P.H. to medical students is delayed until the M.D. degree is conferred
7/1987-6/1988 Occupational Health Research Fellow, Dept. of Environmental Health, Harvard School of Public Health
Internship and Residencies
7/1982-6/1983 Intern in Medicine, Boston City Hospital
7/1983-6/1984 Junior Assistant Resident, Internal Medicine, Boston City Hospital
7/1984-6/1985 Senior Assistant Resident, Internal Medicine, Boston City Hospital
7/1985-6/1987 Resident, Occupational Medicine, Harvard School of Public Health
1999 – International Society for Environmental Epidemiology
1987 – Member, American College of Occupational and Environmental Medicine
1987 – Member, American Public Health Association
1987 – Member, Physicians for Human Rights
2009 – Member, Society for Toxicology
2012 – Member, Canadian Public Health Association
What is the Role of Schools of Public Health in the 21st century? A Panel of Deans (McGill University, May, 2015)
In conversation with Dr. Paul Farmer (with Dean Howard Hu; University of Toronto, June, 2014)
Collaborative Program in Neuroscience Distinguished Lecture by Dr. Howard Hu (University of Toronto, September, 2016)
Asean Institute for Health and Development (6th Asia-Pacific Conference on Public Health, Bangkok, Thailand, August, 2016)
Dean’s Leadership Series: Maximizing Urban Health, Minimizing Climate Impact (DLSPH, May 31, 2017)
Primary Teaching Responsibilities
Introduction to Public Health (Introduction to Public Health Sciences, CHL5004H);
Introduction to Public Health (Determinants of Community Health, UT Medical School);
The Toxicology of Metals (Industrial Toxicology, CHL 5912F);
The Challenges of Environmental Health in a Rapidly-Changing World, from the Molecular to the Global (Doctoral Seminar, Collaborative Doctoral Program in Global Health, CHL 5701H)
Professional Summary & Appointments
Dr. Hu is Professor of Environmental Health, Epidemiology, Global Health, and Medicine and the Founding Dean of the Dalla Lana School of Public Health, a Faculty of the University of Toronto (2012-present). On July 1, 2017, Dr. Hu started a 1-year sabbatical/administrative leave, during which he is pursuing research and other scholarly activities in Seattle, Washington, USA, in part as a Visiting Scholar at the University of Washington School of Public Health. In the meantime, Dr. Adalsteinn Brown has been appointed and is serving as Interim Dean of the School of Public Health.
Dr. Hu is a physician-scientist, trained as an internist and preventive medicine specialist, with a doctoral degree in epidemiology from Harvard. Previously, Dr. Hu had been a tenured Professor of Occupational & Environmental Medicine, Founding Director of the NIEHS Center for Children’s Environmental Health, and Director of the Occupational Medicine Residency at the Harvard School of Public Health and the Channing Laboratory of the Brigham & Women’s Hospital in Boston (1988-2006); and the NSF International Chair of the Department of Environmental Health Sciences, Professor of Environmental Health, Epidemiology and Internal Medicine, and Founding Director of the NIEHS Environmental Health Core Sciences Center at the University of Michigan (2006-2012). Dr. Hu retains an appointment as Adjunct Professor at the University of Michigan.
Since 1990, Dr. Hu has led multi-institutional and international teams of scientists, students and fellows devoted to investigating the environmental, nutritional, social, psychosocial, genetic and epigenetic determinants of chronic disease and impaired child development in population-based studies in the U.S., Mexico, India, China, and elsewhere around the world. His team’s work has generated over 300 publications and won several awards, such as the 1999 Progress and Achievement Award from the U.S. National Institute for Environmental Health Sciences, the 2009 Linus Pauling Lifetime Achievement Award, the 2011 Award of Excellence from the American Public Health Association, and the 2015 John Goldsmith Award for Outstanding Contributions from the International Society for Environmental Epidemiology.
In 1999-2000, Dr. Hu was a Senior Faculty Fulbright Scholar in India. He also served as a member of the Board of Directors and the principal epidemiologist on four fact-finding missions for Physicians for Human Rights; served on the Board of Population and Public Health Practice of the Institute of Medicine of the National Academy of Sciences; and served as the Chair of the Research Commission for the International Physicians for the Prevention of Nuclear War. In the latter capacity, he and colleagues published “Nuclear Wastelands”, which was nominated for the U.S. National Book Award in 1996.
As the Founding Dean of the Dalla Lana School of Public Health, Dr. Hu led Canada’s best and largest School of Public Health , a Faculty within Canada’s best Global University . With the School’s leaders, he advanced a number of innovative initiatives involving healthy cities, big data for population health, Indigenous health, new systems that integrate public health and primary care, social entrepreneurship, and, with its partners around the world, the global agenda of addressing health inequities. Dean Hu also initiated the first major fund-raising campaign for a School of Public Health in Canada, accompanied by the launch of the Dean’s Leadership Lecture Series, a high-profile forum for debating ideas of major regional and global impact. In 2016, Dean Hu was elected to Fellowship in the Canadian Academy of Health Sciences.
1978-1982 National Health Service Corps Scholarship
1985-1988 National Research Service Award
1990-1992 Agency for Toxic Substances and Disease Registry Clinical Environmental Medicine Award
1994 Will Solimene Award of Excellence, American Medical Writers Association, for: Chivian E, McCally M, Hu H, Haines H, eds. Critical Condition: Human Health and the Environment. Cambridge: The MIT Press, 1993.
1997 Alice Hamilton Lecturer, University of California at San Francisco
1998 First Prize for Best Infant Nutrition Research, Instituto Danone, Mexico (for González-Cossío T, Peterson KE, Sanín L, Fishbein SE, Palazuelos E, Aro A, Hernández-Avila M, Hu H. “Decrease in birth weight in relation to maternal bone lead burden.” (Published in Pediatrics)
1999 National Institute for Environmental Health Sciences “Progress and Achievement of the Year Award”, 1998-1999
1999 True Memorial Lecturer, Maine Medical Center, Portland ME.
2000-2001 Faculty Sabbatical Award, Harvard School of Public Health
2000-2001 Senior Fulbright Scholar in India
2001 Hoopes Prize, Faculty Mentorship (for Senior Thesis of Charles Lin, “More than Black and White: Lead Poisoning as an Environmental Justice Issue in Boston”
2003 Best Paper in Preventive Medicine by a Medical Student (for Senior Thesis of Vanitha Janakiraman; Janakiraman V, Hu H, Mercado-Garcia A, Hernandez-Avila M. A randomized crossover trial of nocturnal calcium supplements to suppress bone resorption during pregnancy. Am J Prev Med 2003;24:260-4.). American College of Preventive Medicine, Ulrich and Ruth Frank Foundation for International Health.
2004 Das Travel Grant Award, The South Asia Initiative, Harvard University (for Travel in India)
2005 Adolph G. Kammer Merit in Authorship Award, the American College of Occupational and Environmental Medicine (for Rhodes D, Spiro A, Aro A, Hu H “Relationship of Bone and Blood Lead Levels to Psychiatric Symptoms: The Normative Aging Study”, Published in the Journal of Occupational and Environmental Medicine)
2006 Teacher of the Year Award, Occupational/Environmental Medicine Residents, Harvard School of Public Health
2006 Harriett Hardy Award, the New England College of Occupational and Environmental Medicine
2009 Linus Pauling Award for Lifetime Achievements, American College for the Advancement of Medicine
2010 Nomination to the Institute of Medicine, National Academy of Sciences (not elected this round)
2011 Award for Excellence, American Public Health Association
2015 John R. Goldsmith Award (for Outstanding Contributions to the field), International Society for Environmental Epidemiology
2016 Election to Fellowship, Canadian Academy of Health Sciences
Current Research Projects
Current funded grants
6/1/2012-3/30/2018 (NCE) 1R01ES021446-01, PI, $3,840,000; “Prenatal and Childhood Exposure to Fluoride and Neurodevelopment”
7/1/2012-7/1/2017 European Commission (EC), Funded under FP7-Health, Project 304925, co-Investigator; PI, epidemiologic studies, $6,000,000 E; “A novel micronutrient-based strategy to prevent hearing impairments: test and road to market for age-related hearing loss and preservation of residual hearing”
5/15/2015-5/15/2017 Health Canada; PI, $200,000 (Phase 1); $1,400,000 (proposed Phase 2); “A Community-based First Nation Study of Cancer and the Environment in Northern Ontario”
4/1/13-3/31/18 NIEHS/EPA P01ES022844 (co-inv; PI: Peterson at the University of Michigan) “Lifecourse Exposures & Diet: Epigenetics, Maturation & Metabolic Syndrome.”
4/1/12-3/30/17 NIEHS R01ES013744 (consultant; PI: Wright; Mt Sinai School of Medicine) “Stress-Lead Interactions and Child Development”
7/1/16-6/30/21 CIHR (co-PI; Director; PI: Jeffrey Brook at the Dalla Lana School of Public Health) $4,700,000M CNDN; “CANadian Urban Environmental (CANUE) Health Research Consortium”
Selected Recent Publications (out of over 350; recent)
Ding N, Wang X, Weisskopf MG, Sparrow D, Schwartz J, Hu H, Park SK. Lead-Related Genetic
Loci, Cumulative Lead Exposure and Incident Coronary Heart Disease: The Normative Aging Study. PLoS One. 2016 Sep 1;11(9):e0161472. doi: 10.1371/journal.pone.0161472. PubMed PMID: 27584680; PubMed Central PMCID: PMC5008632.
Goodrich JM, Dolinoy DC, Sanchez BN, Zhang Z, Meeker JD, Mercado-Garcia A, Solano-
Gonzalez M, Hu H, Tellez-Rojo MM, Peterson KE. Adolescent epigenetic profiles and environmental exposures from early life through peri-adolescence. Environmental Epigenetics, 2016; 2(3)1–11, doi: 10.1093/eep/dvw018
Farooqui Z, Bakulski KM, Power MC, Weisskopf MG, Sparrow D, Spiro A 3rd, Vokonas PS,
Nie LH, Hu H, Park SK. Associations of cumulative Pb exposure and longitudinal changes in Mini-Mental Status Exam scores, global cognition and domains of cognition: The VA Normative Aging Study. Environ Res. 2017 Jan;152:102-108. doi: 10.1016/j.envres.2016.10.007. PubMed PMID: 27770710; PubMed Central PMCID: PMC5135609.
Somers EC, Monrad SU, Warren JS, Solano M, Schnaas L, Hernandez-Avila M, Tellez-Rojo
M, Hu H. Antinuclear antibody prevalence in a general pediatric cohort from Mexico City: discordance between immunofluorescence and multiplex assays. Clin Epidemiol. 2016 Dec 20;9:1-8. doi: 10.2147/CLEP.S121632. eCollection 2017. PubMed PMID: 28053555; PubMed Central PMCID: PMC5192054.
Bashash M, Connors JM, Gascoyne RD, Meissner B, Schuetz JM, Leach S, Slack GW, Berry
R, Hu H, Sehn LH, Brooks-Wilson AR, Spinelli JJ. Genetic polymorphism at BCL2 as a predictor for rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone efficacy in patients with diffuse large B-cell lymphoma. Haematologica. 2017 May;102(5):e199-e202. doi: 10.3324/haematol.2016.159087. Epub 2017 Feb 2. PubMed PMID: 28154089; PubMed Central PMCID: PMC5477624.
Hu H, Galea S, Rosella L, Henry D. Big Data and Population Health: Focusing on the Health
Impacts of the Social, Physical, and Economic Environment. Epidemiology. 2017 Jul 4. doi: 10.1097/EDE.0000000000000711. [Epub ahead of print] PubMed PMID: 28682850.
Wang X, Ding N, Tucker KL, Weisskopf MG, Sparrow D, Hu H, Park SK. A Western Diet
Pattern Is Associated with Higher Concentrations of Blood and Bone Lead among Middle-Aged and Elderly Men. J Nutr. 2017 Jul;147(7):1374-1383. doi: 10.3945/jn.117.249060. Epub 2017 Jun 7. PubMed PMID: 28592514; PubMed Central PMCID: PMC5483966.
Bashash M, Thomas D, Hu H, Martinez-Mier EA, Sanchez BN, Basu N, Peterson KE, Ettinger
AS, Wright R, Zhang Z, Liu Y, Schnaas L, Mercado-Garcia A, Téllez-Rojo MM, Hernández-Avila M. Prenatal Fluoride Exposure and Cognitive Outcomes in Children at 4 and 6-12 Years of Age in Mexico. Environ Health Perspec 2017 Environ Health Perspect. 2017 Sep 19;125(9). doi: 10.1289/EHP655. PubMed PMID: 28937959.Available at https://ehp.niehs.nih.gov/ehp655/
Wei X, Ge E, Min F, Qiu H, Hu H, Tian L, Wang X, Xue G. Ambient sulfur dioxide levels
associated with reduced risk of initial outpatient visits for tuberculosis: a population based time series analysis. Environ Pollution (in press).
Tse LA, Lee PMY, Ho WM, Lam AT, Lee MK, Ng SSM, He Y, Leung KS, Hartle JC, Hu H,
Kan H, Wang F, Ng CF. Bisphenol A and other environmental risk factors for prostate cancer in Hong Kong. Environ Int. 2017 Oct;107:1-7. doi: 10.1016/j.envint.2017.06.012. Epub 2017 Jun 20. PubMed PMID: 28644961.
Liu SH, Bobb JF, Lee KH, Gennings C, Claus Henn B, Bellinger D, Austin C, Schnaas L, Tellez-Rojo MM, Hu
H, Wright RO, Arora M, Coull B. Lagged kernel machine regression for identifying time windows of susceptibility to exposures of complex metal mixtures. Biostatistics (in press).
Taskforce on Environmental Health (Hu: Taskforce Chair). Time for Leadership: Recognizing
and Improving Care for those with ME/CFS, FM and ES/MCS. Interim Report. Ministry of Health and Longterm Care, Province of Ontario. July, 2017
Hu H. Heavy Metal Poisoning. In: Jameson JL, Fauci AS, Kasper DL, Hauser SL, Longo DL,
Loscalzo J, eds. Harrison’s Principles of Internal Medicine, (20th edition). New York: McGraw-Hill 2017 (in press).