Faculty Member

Lucia Mirea PhD

Email Address(es)
LMirea@mtsinai.on.ca
Office Phone
416-586-4800 x4935
Office Address
Maternal-Infant Care Research Centre (MiCare), Mount Sinai Hospital 700 University Avenue, Suite 8-500 Toronto, Ontario M5G 1X6
Division(s)/Office
Biostatistics Division
Position
Assistant Professor
SGS Status
Associate Member
Appointment Status
Status Only

Research Interests

Statistical genetics
Clinical prediction models and validation
Causal inference
Spatial analyses

Primary Teaching Responsibilities

Practicum supervisor for CHL5207Y/5208Y "Laboratory in Statistical Design and Analysis"

Honours & Awards

Doctoral Research Award, Canadian Institutes for Health Research, 2005-2008

Best Trainee Oral Presentation, 5th Annual Genetic Epidemiology and Statistical Genetics Meeting, 2010

Current Research Projects

1. Genetic association analyses combining individual and family data
2. Heritability of preterm birth complications
3. Clinical prediction models and validation
4. Propensity score analyses of ligation surgery in preterm neonates
5. Spatial mapping of perinatal outcomes

Representative Publications

Mirea L, Infante-Rivard C, Sun L, Bull SB (2011) Strategies for genetic association analyses combining unrelated case-control individuals and family trios. American Journal of Epidemiology (To appear).

Campitelli M, Chiarelli AM, Mirea L, Stewart L, Glendon G, Ritvo P, Andrulis IL, Knight JA (2011) Adherence to breast and ovarian cancer screening recommendations for female relatives from the Ontario Site of the Breast Cancer Family Registry The European Journal of Cancer Prevention 20(6):492-500.

Mirea L, Sun L, Stafford JE, Bull SB (2010) Using evidence for population stratification bias in combined individual- and family-level genetic association analyses of quantitative traits. Genetic Epidemiology 34(5):502-511.

Zhang LR, Chiarelli AM, Glendon G, Mirea L, Edwards S, Knight JA, Andrulis IL, Ritvo P (2010) Influence of perceived breast cancer risk on screening behaviors of female relatives from the Ontario Site of the Breast Cancer Family Registry. The European Journal of Cancer Prevention 20(4):255-62.

Sheppard AJ, Chiarelli AM, Marrett LD, Mirea L, Nishri ED, Trudeau ME and the Aboriginal Breast Cancer Study Group (2010) Detection of later stage breast cancer in First Nations women in Ontario, Canada. Canadian Journal of Public Health 101(1):101-105.

Infante-Rivard C, Mirea L, Bull SB (2009) Combining case-control and case-trio data from the same population in genetic association analyses: overview of approaches and illustration with a candidate gene study. American Journal of Epidemiology. 170(5):657-64.

Paterson AD, Lopes-Virella MF, Waggott D, Boright AP, Hosseini SM, Carter RE, Shen E, Mirea L, Bharaj B, Sun L, Bull SB; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group (2009) Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin. Arteriosclerosis, Thrombosis and Vascular Biology 29(11):1958-67.

Rohlfs RV, Taylor C, Mirea L, Bull SB, Corey M, Anderson AD (2007) One-stage design is empirically more powerful than two-stage design for family-based genome-wide association studies. BMC Genetics Proc. 1(Suppl 1):S137.

Mirea L, Briollais L, Bull S (2004) Tests for covariate-associated heterogeneity in IBD allele sharing of affected relatives. Genetic Epidemiology 26:44-60.

Mirea L, Bull SB, Silverberg MS, Steinhart AH, Wade JA, Siminovitch KA (2002) Case study in data analysis: The genetic analysis of inflammatory bowel disease. Canadian Journal of Statistics 30(1):138-144.