Faculty Member

Andrew Willan PhD-Biostatistics, MSc-Statistics, BEd-Math and PHE, BA-Economics and Math

Email Address(es)
andy@andywillan.com
Office Phone
+1-416-813-2166
Office Address
Program in Child Health Evaluative Sciences/SickKids Research Institute 686 Bay Street, Room 11.9708 Toronto, ON M5G 1E2
Website(s)
Andy Willan's Home Page, Internet Randomization Service
Curriculum Vitae
Download
Division(s)/Office
Biostatistics Division
Position
Professor
SGS Status
Full Member
Appointment Status
Status Only

Research Interests

  • Clinical trials methodology
  • Statistical analysis of cost-effectiveness data
  • Expected value of information and optimal design of clinical trials
  • Bayesian analysis of randomised clinical trials

Education & Training History

  • PhD in Biostatistics from the Department of Epidemiology and Biostatistics at the University of Western Ontario, London ON, 1979.
  • MSc in Statistics from Queen’s University, Kingston ON, 1976.
  • BEd in Mathematics and Physical Education from Queen’s University, Kingston ON, 1972.
  • BA in Economics and Mathematics from York University, Toronto ON, 1970.

Other Affiliations

Senior Scientist Emeritus

Program in Child Health Evaluative Sciences

SickKids Research Institute

Professor Emeritus

Department of Clinical Epidemiology and Biostatistics

McMaster University

Primary Teaching Responsibilities

  • Advanced Statistical Methods for Clinical Trials (CHL 5225 H)

Honours & Awards

  • TBA

Current Research Projects

  • Canadian Institutes of Health Research, The Twin Birth Study (200211MCT-110280). Barrett J (Principal Investigator), Willan A, and 7 others. $8,608,045, 2003-2014.
  • National Science and Engineering Council, Expected Value of Information and Optimal Trial Design (RGPIN 44868-08). Willan AR (Principal Investigator) $70,000, 2008-2013.
  • Canadian Institutes of Health Research, The Bedside Paediatric Early Warning System: a cluster randomized trial of mortality and processes of care. Parshuram C (Principal Investigator),Willan AR, and 13 others. $3,959,716, 2010-2014.
  • Canadian Institutes of Health Research, Sustainability of a multidimensional knowledge translation intervention to improve paediatric pain practices and outcomes. Bonnie Stevens (Principal Investigator), Willan AR, and 20 others. $998,061, 2011-2014.
  • Bill and Belinda Gates Foundation, Parathyroid-vitamin D axis dysregulation in early-onset infant stunting in resource-poor settings. Dan Roth (Principal Investigator), Willan AR,and 5 others. $1,999,993, 2012-2016.
  • Canadian Institutes of Health Research,Impact of Emergency Department Probiotic Treatment of Pediatric Gastroenteritis: Randomized Controlled Trial. Stephen Freedman (Principal Investigator), Willan AR, and 9 others. $2,231,300, 2013-2018.
  • Canadian Institutes of Health Research, Sucrose Practices for Pain in Neonates (SPiN); A Program of Research. Bonnie Stevens (Principal Investigator),Willan AR, and 12 others. $1,246,500, 2013-2018.

Representative Publications

  • Willan AR. Accounting for treatment by center interaction in sample size determinations and the use of surrogate outcomes in the pessary for the prevention of preterm birth trial: a simulation study. BMC Trials 2016 17(1):310.
  • Chan KKW, Xie F, Willan AR. Gupta M, Pullenayegum E. Underestimation of variance of predicted health utilities derived from multi-attribute utility instruments: the use of multiple imputation as a possible solution. Medical Decision Making 2016; DOI 1011.77/0272989X16650181.
  • Chen MH, Willan AR. Value of information methods for assessing a new diagnostic test. Statistics in Medicine 2014; 33(11):1801-1815.
  • Chan KKW, Willan AR, Gupta M, Pullenayegum E. Underestimation of Uncertainties in Health Utilities derived from Mapping Algorithms involving Health Related Quality of Life Measures: Statistical Explanations and Potential Remedies. Medical Decision Making 2014; 34(7):863-872.
  • Willan AR. Bayesian decision theory and the design and analysis of randomized clinical trials. In: Development in Statistical Evaluation of Clinical Trials. K. van Montfort, J. Oud und W. Ghidey (ed). Springer-Verlag 2014.
  • Willan AR. Bayesian methods provide important advantages for the design, analysis and interpretation of clinical studies. In: Important Considerations for Clinical Trial Methodologies. Future Medicine 2013. doi: 10.4155/9781909453319
  • Chen MH, Willan AR. Determining optimal sample sizes for multistage adaptive randomized clinical trials from an industry perspective using value of information methods. Clinical Trials 2013; 10(1):54–62.
  • Eckermann S, Willan AR. Optimal global VOI trials: better aligning manufacturer and decision maker interests and enabling feasible risk sharing. PharmacoEconomics 2013; 31(5):393-401,
  • Hossain A, Willan AR, Beyene J. A flexible nonparametric approach to find candidate genes associated to disease in microarray experiments. Journal of Bioinformatics and Computational Biology 2013; 11(2):1250021 (19 pages).
  • Hossain A, Willan AR, Beyene J. An improved method on Wilcoxon rank sum test for gene selection from microarray experiments. Communications in Statistics 2013; 42(7):1563-1577
  • Willan AR, Goeree R, Boutis K. Value of Information methods for planning and analyzing clinical studies optimize decision making and research planning. Journal of Clinical Epidemiology 2012; 65(8):870-876
  • Willan AR, Eckermann S. Value of information and pricing new health care interventions. PharmacoEconomics 2012; 30(6):447-459.
  • Willan AR, Eckermann S. Accounting for between-study variation in incremental net benefit in value of information methodology. Health Economics 2012; 21(10):1183–1195.
  • Pullenayegum EM, Willan AR. Marginal models for censored longitudinal cost data: appropriate working variance matrices in inverse-probability-weighted GEEs can improve precision. The International Journal of Biostatistics 2011; 7(1), Article 14.
  • Willan AR. Sample size determination for cost-effectiveness trials. PharmacoEconomics 2011; 29(11):933-949.
  • Eckermann S, Willan AR. Presenting and summarizing cost and effect evidence to best inform inference and societal decision making when comparing multiple strategies. PharmacoEconomics 2011; 29(7):563-577.
  • Eckermann S, Coory M, Willan AR. Consistently estimating risk difference when translating evidence to jurisdiction of interest. PharmacoEconomics 2011; 29(2):87-96.
  • Eckermann S, Karnon J, Willan AR. The value of information: Best informing research design and prioritization using current methods. PharmacoEconomics 2010; 28(9):699-709.
  • Willan AR, Eckermann S. Optimal clinical trial design using value of information methods with imperfect implementation. Health Economics 2010; 19:549-561.
  • Hossain A, Beyene J, Willan AR, Hu P. A flexible approximate likelihood ratio test for detecting differential expression in microarray data. Computational Statistics and Data Analysis 2009; 53(10):3685-3695.
  • Eckermann S, Coory M, Willan AR. Indirect comparison: relative risk fallacies and odds solution. Journal of Clinical Epidemiology 2009; 62(10): 1031-1036.
  • Eckermann S, Willan AR. Globally optimal trial design for local decision making. Health Economics 2009; 18(2): 203-216.
  • Willan AR. Optimal sample size determinations from an industry perspective based on the expected value of information. Clinical Trials 2008; 5(6): 587-594.
  • Willan AR, Kowgier ME. Determining optimal sample sizes for multi-stage randomized clinical trials using value of information methods. Clinical Trials 2008; 5(4): 289-300.