Public health and health systems researchers reduce widespread antibiotic misuse in rural China

October 26/2017


An international team led by Professor Xiaolin Wei has significantly reduced the widespread practice of prescribing antibiotics to kids with common colds in rural China. Their results were published October 25, 2017 in the The Lancet Global Health.

Prof Xiaolin Wei

Prof Xiaolin Wei

“Antibiotic misuse is high because parents demand care for their children, and for many, care equals medicine,” said Xiaolin Wei, lead author and Associate Professor of Health Systems and Clinical Public Health in Asia with the Dalla Lana School of Public Health and the Institute of Health Policy, Management and Evaluation.

Health practitioners working in primary care clinics are a major source of antibiotic overuse. Upper respiratory tract infections, such as common colds, sore throats or ear ache, are typically viral infections that don’t require antibiotics. In developing countries, antibiotics are given to up to 80 per cent of patients who have upper respiratory tract infections, while this rate may be up to 40 per cent in North America.

Inappropriate antibiotic prescribing contributes to antimicrobial resistance, which makes infections and illnesses more difficult to treat and puts strain on the health-care system due to increased hospital stays and expensive treatments. Most research on reducing antibiotic use is conducted in Europe, U.S. and Canada, which have limited application to developing countries.

“It’s more challenging to talk about antimicrobial resistance in rural areas because there’s a lack of knowledge about when to use antibiotics and there’s less drug regulation. We need to work closely with health policy-makers, public health officers and clinicians to adapt the interventions into the local health system,” said Wei.

Prof Wei with public health officials from the Centre for Disease Control at the provincial and county levels, township hospital directors, and researchers

The study, “Effect of a training and educational intervention for physicians and caregivers on antibiotic prescribing for upper respiratory tract infections in children at primary care facilities in rural China: a cluster-randomised controlled trial,” was published on October 25, 2017 in The Lancet Global Health and is the first to examine effectiveness of implementing antibiotics reduction strategies in primary care facilities in a developing country.

Wei worked with Professor Ross Upshur, DLSPH’s Clinical Public Health Division Head, Professor John Walley from the University of Leeds, Professor Qiang Sun, from Shandong University, Dr. Mei Lin, from the Guangxi Centre for Disease Control and Prevention, and Professor Yan Guo, from Peking University, to conduct a randomized control trial among 1.4 million residents in Guangxi, a province in south western China

Click here to read the Leeds Institute of Health Sciences article

The intervention included clinician guidelines and training on appropriate prescribing, monthly prescribing peer-review meetings to measure guideline adherence, and caregiver education about appropriate treatment for upper respiratory tract infections. Videos and pamphlets helped educate patients and families, and physicians were trained to communicate antibiotic prescribing efficacy messaging in the clinic.

The intervention reduced antibiotic prescription by more than half — from 82 per cent to 40 per cent — while the rate went from 75 per cent to 70 per cent in the business-as-usual group.

Caregiver feedback was mixed, but Wei said that there’s a need for more education about antibiotics.

“Educating family physicians in rural China on how to use antibiotics, and giving them the confidence not to prescribe when unnecessary, is critical,” said Wei.

The intervention strategies will be scaled up to support the national antimicrobial stewardship policy in China and can also be adapted to other developing countries facing similar antibiotic overuse challenges.