Faculty Member

Mohammad Reza Akbari M.D., Ph.D.

Email Address(es)
mohammad.akbari@utoronto.ca
Office Phone
+416-545-7130
Office Address
76 Grenville St Room E1-10 Toronto, Ontario M5S 1B2
Website(s)
Women's College Research Institute
Division(s)/Office
Epidemiology Division
Position
Assistant Professor
SGS Status
Associate Member
Appointment Status
Status Only

Research Interests

Dr. Akbari’s research is focused on the study of genetic susceptibility to breast, ovarian, esophageal, pancreatic and prostate cancers. He looks for new genes responsible for these different hereditary cancers. Dr. Akbari is also interested in characterizing the role and impact that known cancer genes have on risk. He is working to develop evidence-based cancer treatments that are personalized to patients who carry a mutation.

Education & Training History

2010-2011: Postdoctoral fellowship in Genetic Epidemiology, Women’s College Research Institute, University of Toronto, Toronto, Canada

2006-2010: PhD in Molecular Human Genetics, Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Canada

2002-2004: Research fellowship in gastroenterology, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran

2000-2001: Internship, Tehran University Hospitals (Dr. Shariati , Imam Khomeini, Sina, Bahrami, Amir-A-lam), Tehran, Iran

1994- 2000: MD Degree from Tehran University of Medical Sciences (TUMS), Tehran, Iran

Other Affiliations

Womwn's College Research Institute, Women's College Hospital, University of Toronto

Primary Teaching Responsibilities

Assistant Professor, Dalla Lana School of Public Health, Faculty of Medicine, University of Toronto

Scientist, Women’s College Research Institute, Women's College Hospital, University of Toronto

Honours & Awards

2009: Awarded Ontario Graduate Scholarship (OGS) for studying Human Genetics in 2009-2010 academic year

2005: Awarded a UICC International Cancer Technology Transfer Fellowship

1993: Bronze medal winner of 25th International Chemistry Olympiad (I.Ch.O) in Italy

1992: Gold medal winner of the National Chemistry Olympiad in Iran

Current Research Projects

1- Identifying new genes for breast cancer in Polish founder population using exome sequencing approach

2- Identifying new genes for ovarian cancer in Jewish founder population using exome sequencing approach

3- DNA methylation pattern in bilateral breast cancer

4- Validating bench-top next generation sequencers for clinical cancer genetics screening

5- Looking for breast cancer predisposing recessive genes in affected individuals from consanguine parents using homozygosity mapping

6- Searching for esophageal squamous cell cancer predisposing genes using population based Identity-by-descent approach in Turkmen population

7- Response to Cis-platinum in pancreatic cancer patients carrying BRCA1 or BRCA2 mutation

Representative Publications

1- Akbari MR, Trachtenberg J, Lee J, Tam S, Bristow R, Loblaw A, Narod SA, Nam RK. Association between germline HOXB13 G84E mutation and risk of prostate cancer. JNCI 2012;104: 1260-2.

2- Akbari MR, Zhang S, Fan I, Royer R, Li S, Risch H, McLaughlin J, Rosen B, Sun P, Narod SA. Clinical impact of unclassified variants of the BRCA1 and BRCA2 genes. J Med Genet. 2011 Nov;48(11):783-6.

3- Lurie G, Gaudet MM, Spurdle AB, Carney ME, Wilkens LR, Yang HP, Weiss NS, Webb PM, Thompson PJ, Terada K, Setiawan VW, Rebbeck TR, Prescott J, Orlow I, O'Mara T, Olson SH, Narod SA, Matsuno RK, Lissowska J, Liang X, Levine DA, Le Marchand L, Kolonel LN, Henderson BE, Garcia-Closas M, Doherty JA, De Vivo I, Chen C, Brinton LA, Akbari MR; Australian National Endometrial Cancer Study Group; Epidemiology of Endometrial Cancer Consortium (E2C2), Goodman MT. The obesity-associated polymorphisms FTO rs9939609 and MC4R rs17782313 and endometrial cancer risk in non-Hispanic white women. PLoS One. 2011 Feb 8;6(2):e16756.

4- Akbari MR, Malekzadeh R, Lepage P, Roquis D, Sadjadi AR, Aghcheli K, Yazdanbod A, Shakeri R, Bashiri J, Sotoudeh M, Pourshams A, Ghadirian P, Narod SA. Mutations in Fanconi Anemia Genes and the Risk of Esophageal Cancer. Hum Genet 2010 may;129(5):573-82.

5- Akbari MR, Tonin P, Foulkes WD, Ghadirian P, Tischkowitz M, Narod SA. RAD51C germline mutations in breast and ovarian cancer patients. Breast Cancer Res. 2010 Aug 19;12(4):404.

6- Akbari MR, Malekzadeh R, Shakeri R, Nasrollahzadeh D, Foumani M, Sun Y, Pourshams A, Sadjadi A, Jafari E, Sotoudeh M, Kamangar F, Boffetta P, Dawsey SM, Ghadirian P, Narod SA. Candidate gene association study of esophageal squamous cell carcinoma in a high-risk region in Iran. Cancer Res. 2009 Oct 15; 69 (20):7994-8000.

7- Ghadirian P, Robidoux A, Zhang P, Royer R, Akbari MR, Zhang S, Fafard E, Costa M, Martin G, Potvin C, Patocskai E, Larouche N, Younan R, Nassif E, Giroux S, Narod SA, Rousseau F, Foulkes WD. The contribution of founder mutations to early-onset breast cancer in French-Canadian women. Clin Genet 2009 Nov; 76 (5):421-6.

8- Bentov Y, Brown TJ, Akbari MR, Royer R, Risch H, Rosen B, McLaughlin J, Sun P, Zhang S, Narod SA, Casper RF. Polymorphic variation of genes in the fibrinolytic system and the risk of ovarian cancer.. PLoS One. 2009 Jun 15; 4 (6):e5918.

9- Ginsburg OM, Akbari MR, Aziz Z, Young R, Lynch H, Ghadirian P, Robidoux A, Londono J, Vasquez G, Gomes M, Costa MM, Dimitrakakis C, Gutierrez G, Pilarski R, Royer R, Narod SA. The prevalence of germ-line TP53 mutations in women diagnosed with breast cancer before age 30. Fam Cancer. 2009; 8 (4):563-7.

10- Setiawan VW, Doherty JA, Shu XO, Akbari MR, Chen C, De Vivo I, Demichele A, Garcia-Closas M, Goodman MT, Haiman CA, Hankinson SE, Henderson BE, Horn-Ross PL, Lacey JV Jr, Le Marchand L, Levine DA, Liang X, Lissowska J, Lurie G, McGrath M, Narod SA, Rebbeck TR, Ursin G, Weiss NS, Xiang YB, Yang HP, Zheng W, Olson SH. Two estrogen-related variants in CYP19A1 and endometrial cancer risk: a pooled analysis in the Epidemiology of Endometrial Cancer Consortium. Cancer Epidemiol Biomarkers Prev. 2009 Jan; 18 (1):242-7.

11- Akbari MR, Ghadirian P, Robidoux A, Foumani M, Sun Y, Royer R, Zandvakili I, Lynch H, Narod SA. Germline RAP80 mutations and susceptibility to breast cancer. Breast Cancer Res Treat. 2009 Jan; 113 (2):377-81.

12- Akbari MR, Malekzadeh R, Nasrollahzadeh D, Amanian D, Islami F, Li S, Zandvakili I, Shakeri R, Sotoudeh M, Aghcheli K, Salahi R, Pourshams A, Semnani S, Boffetta P, Dawsey SM, Ghadirian P, Narod SA. Germline BRCA2 mutations and the risk of esophageal squamous cell carcinoma. Oncogene. 2008 Feb 21; 27 (9):1290-6.

13- Rodriguez RC, Esperon AA, Ropero R, Rubio MC, Rodriguez R, Ortiz RM, Anta JJ, de los Rios M, Carnesolta D, del Olivera MC, Vansam SS, Royer R, Akbari MR, Donenberg T, Narod SA. Prevalence of BRCA1 and BRCA2 mutations in breast cancer patients from Cuba. Fam Cancer. 2008; 7 (3) :275-9.

14- Foulkes WD, Ghadirian P, Akbari MR, Hamel N, Giroux S, Sabbaghian N, Darnel A, Royer R, Poll A, Fafard E, Robidoux A, Martin G, Bismar TA, Tischkowitz M, Rousseau F, Narod SA. Identification of a novel truncating PALB2 mutation and analysis of its contribution to early-onset breast cancer in French-Canadian women. Breast Cancer Res. 2007; 9 (6):R83.

15- Malekzadeh R, Akbari MR. Prevalence of gluten-sensitive enteropathy and coeliac disease in Iran. Eur J Gastroenterol Hepatol. 2007 Sep;19(9):825-6.

16- Zogopoulous G, Rothenmund H, Eppel A, Ash C, Akbari MR, Hedley D, Narod SA, Gallinger S. The P239S palladin variant does not account for a significant fraction of hereditary or early onset pancreas cancer. Hum Genet. 2007 Jun;121(5):635-7.