Faculty Member

Rayjean J. Hung

Email Address(es)
rayjean.hung@lunenfeld.ca
Office Phone
(416) 586-4750
Office Address
Samuel Lunenfeld Research Institute of Mount Sinai Hospital 60 Murray St. Box 18 Toronto, ON M5T 3L9
Website(s)
Rayjean J. Hung Epidemiology Research Group, North American Wilms Tumor Study, International Lung Cancer Consortium
Division(s)/Office
Epidemiology Division
Position
Associate Professor
SGS Status
Full Member
Appointment Status
Status Only

Research Interests

  • Cancer Epidemiology
  • Molecular and Genomic Epidemiology
  • Childhood Cancer Epidemiology
  • Perinatal Risk Factors
  • Methodology development
  • Hierarchical modeling

Education & Training History

  • Postdoctoral Fellowship, International Agency For Research on Cancer, World Health Organization, Lyon, France
  • Ph.D., Epidemiology, University of California at Los Angeles
  • M.S., Epidemiology, University of California at Los Angeles
  • B.V.M., Veterinary Medicine, National Taiwan University

Other Affiliations

  • 2017 – present: Publication Committee, International Genetic Epidemiology Committee (IGES)
  • 2016 – present: Steering Committee, Ontario Birth Study
  • 2012 – present: Epidemiology Steering Committee. Children’s Oncology Group. US
  • 2010 – 2015: Steering Committee and Chair of the Epidemiology and Clinical Working Group, The Cross Cancer Genetic Associations and Mechanisms in Oncology (GAME-ON) Initiative. National Cancer Institute, US
  • 2010 – present: Steering Committee, Strategic Training for Advanced Genetic Epidemiology (STAGE) program, University of Toronto
  • 2005 – present: Scientific Coordinator, International Lung Cancer Consortium.

Primary Teaching Responsibilities

  • Cancer Epidemiology

Professional Summary & Appointments

Dr. Hung’s current primary appointment is at the Lunenfeld-Tanenbaum Research Institute of the Sinai Health System as a Senior Investigator. She was recruited to Toronto in 2007 after an international search from the International Agency for Research on Cancer (IARC) in Lyon, France, where she was also appointed as a Research Faculty at the University of California at Berkeley.

Dr. Hung has more than 10 years of research experiences in cancer epidemiology at the international level, and has conducted several multicenter case-control studies on lung, head and neck, kidney, pancreas and childhood cancer. Dr. Hung has a stellar record of publication in the international peer review journals particularly in the field of genetic and molecular epidemiology, including high impact journals such as Nature, Nature Genetics, the Journal of National Cancer Institute, and Human Genetics. She was awarded the prestigious Cancer Care Ontario Research Chair in Population Studies in 2008 and recently the Researcher Award from Ontario Ministry of Research and Innovation. Dr. Hung is the PI of several large-scale epidemiological projects on adult cancers, pediatric tumors and studies cross multiple cancer sites. She is the Epidemiology and Clinical Working Group Chair for the GAME-ON (Genetic Associations and Mechanisms in Oncology) Network of Consortia of NCI, and Epidemiology Steering Committee member of Children’s Oncology Group.

Honours & Awards

  • 2015, Llyod S.D. Fogler Award for Research Excellence, Sinai Health System, Canada
  • 2008-2013, Research Chair in Population Studies, Cancer Care Ontario, Toronto, Canada
  • 2011, Early Researcher Award. Ontario Ministry of Research and Innovation, Canada
  • 2012, New Generation Scientist Award. Mount Sinai Hospital, Canada

Recent Research Projects

  • 2017- present: Integrative Analysis of Lung Cancer Etiology and Risk
  • 2012 – present: Cell-Free DNA Whole-genome Methylation Profiles for Pancreatic Cancer Early Detection and Clinical Outcome
  • 2012 – Present: The Cross Cancer Genetic Associations and Mechanisms in Oncology (GAME-ON) Initiative of National Cancer Institute.
  • 2011- Present: North American Wilms Tumor Study
  • 2008- Present: Multicancer Case-Control Study in Ontario
  • 2007- Present: Genomewide Association Studies of Lung Cancer
  • 2006- Present: International Study of non-CNS Embryonal Tumors
  • 2004- Present: International Lung Cancer Consortium

Representative Publications

  • McKay JD*, Hung RJ*, Han Y, Zong X, Carreras-Torres R, Christiani DC, Caporaso NE, Johansson M, Xiao X, Li Y, Byun J, Dunning A, Pooley KA, Qian DC, Ji X, Liu G, Timofeeva MN, Bojesen SE, Wu X, Le Marchand L, Albanes D, Bickeböller H, Aldrich MC, Bush WS, Tardon A, Rennert G, Teare MD, Field JK, Kiemeney LA, Lazarus P, Haugen A, Lam S, Schabath MB, Andrew AS, Shen H, Hong YC, Yuan JM, Bertazzi PA, Pesatori AC, Ye Y, Diao N, Su L, Zhang R, Brhane Y, Leighl N, Johansen JS, Mellemgaard A, Saliba W, Haiman CA, Wilkens LR, Fernandez-Somoano A, Fernandez-Tardon G, van der Heijden HFM, Kim JH, Dai J, Hu Z, Davies MPA, Marcus MW, Brunnström H, Manjer J, Melander O, Muller DC, Overvad K, Trichopoulou A, Tumino R, Doherty JA, Barnett MP, Chen C, Goodman GE, Cox A, Taylor F, Woll P, Brüske I, Wichmann HE, Manz J, Muley TR, Risch A, Rosenberger A, Grankvist K, Johansson M, Shepherd FA, Tsao MS, Arnold SM, Haura EB, Bolca C, Holcatova I, Janout V, Kontic M, Lissowska J, Mukeria A, Ognjanovic S, Orlowski TM, Scelo G, Swiatkowska B, Zaridze D, Bakke P, Skaug V, Zienolddiny S, Duell EJ, Butler LM, Koh WP, Gao YT, Houlston RS, McLaughlin J, Stevens VL, Joubert P, Lamontagne M, Nickle DC, Obeidat M, Timens W, Zhu B, Song L, Kachuri L, Artigas MS, Tobin MD, Wain LV; SpiroMeta Consortium, Rafnar T, Thorgeirsson TE, Reginsson GW, Stefansson K, Hancock DB, Bierut LJ, Spitz MR, Gaddis NC, Lutz SM, Gu F, Johnson EO, Kamal A, Pikielny C, Zhu D, Lindströem S, Jiang X, Tyndale RF, Chenevix-Trench G, Beesley J, Bossé Y, Chanock S, Brennan P, Landi MT, Amos CI. Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Nat Genet. 2017 Jul;49(7):1126-1132.
  • Zong X, Pole JD, Grundy PE, Mahmud, SM, Parker L, Hung RJ.  Second Malignant Neoplasms after Childhood Non-CNS Embryonal Tumors in North America: a population-based study. European Journal of Cancer, 2017, 84C:173-183
  • Fehringer G, Kraft P, Pharoah PD, Eeles RA, Chatterjee N, Schumacher FR, Schildkraut JM, Lindstrom S, Brennan P, Bickeböller H, Houlston RS, Landi MT, Caporaso NE, Risch A, Amin Al Olama A, Berndt SI, Giovannucci E, Gronberg H, Kote-Jarai Z, Ma J, Muir K, Stampfer MJ, Stevens VL, Wiklund F, Willett WC, Goode EL, Permuth JB, Risch HA, Reid BM, Bezieau S, Brenner H, Chan AT, Chang-Claude J, Hudson TJ, Kocarnik J, Newcomb PA, Schoen RE, Slattery ML, White E, Adank MA, Ahsan H, Aittomaki K, Baglietto L, Blomquist C, Canzian F, Czene K, Dos Santos Silva I, Eliassen AH, Figueroa JD, Flesch-Janys D, Fletcher O, Garcia-Closas M, Gaudet MM, Johnson N, Hall P, Hazra A, Hein R, Hofman A, Hopper JL, Irwanto A, Johansson M, Kaaks R, Kibriya MG, Lichtner P, Liu JJ, Lund E, Makalic E, Meindl A, Müller-Myhsok B, Muranen TA, Nevanlinna H, Peeters PH, Peto J, Prentice RL, Rahman N, Sanchez MJ, Schmidt DF, Schmutzler RK, Southey MC, Tamimi RM, Travis RC, Turnbull C, Uitterlinden AG, Wang Z, Whittemore AS, Yang XR, Zheng W, Rafnar T, Gudmundsson J, Stacey SN, Stefansson K, Sulem P, Chen YA, Tyrer JP, Christiani DC, Wei Y, Shen H, Hu Z, Shu XO, Shiraishi K, Takahashi A, Bossé Y, Obeidat M, Nickle D, Timens W, Freedman ML, Li Q, Seminara D, Chanock SJ, Gong J, Peters U, Gruber SB, Amos CI, Sellers TA, Easton DF, Hunter DJ, Haiman CA, Henderson BE, Hung RJ. Cross-cancer genome-wide association analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations. Cancer Research, 2016, 76(17):5103-14
  • Hung RJ, Ulrich CM, Goode EL, Brhane Y, Muir K, Chan AT, Le Marchand L, Schildkraut J, Witte J S., Eeles R, Boffetta P., Spitz MR, Poirier JG, Rider DN, Fridley BL, Chen Z, Haiman C, Schumacher F, Easton DF, Landi MT, Brennan P, Houlston R, Christiani D., Field JK, Bickeboller H., Risch A, Kote-Jarai Z., Wiklund F, Gronberg H, Chanock S, Berndt SI, Kraft P, Lindstrom S, Al Olama AA, Song H, Phelan C, Wentzensen N, Peters U, Slattery ML, Sellers TA, Gruber SB, Hunter DJ, Amos CI & Henderson B. Cross Cancer Genomic Investigation of Inflammation Pathway Based on Five Common Cancers: Lung, Ovary, Prostate, Breast and Colorectal Cancer. Journal of the National Cancer Institute, 2015 107 (11): djv246
  • Zhang LR, Morgenstern H, Greenland S, Chang SC, Lazarus P, Teare MD, Woll PJ, Orlow I, Cox B, Brhane Y, Liu G, Hung RJ.  Cannabis smoking and lung cancer risk: pooled analysis in the International Lung Cancer Consortium. International Journal of Cancer, 2015 136(4):894-903
  • Poirier JG, Brennan P, McKay JD, Spitz MR, Bickeböller H, Risch A, Liu G, Le Marchand L, Tworoger S, McLaughlin J, Rosenberger A, Heinrich J, Brüske I, Muley, Henderson BE, Wilkens LR, Zong X,  Li Y, Hao K, Timens W, Bossé Y, Sin DD, Obeidat M,  Amos CI, Hung RJ. Informed genome-wide association analysis with family history as a secondary phenotype identifies novel loci of lung cancer.  Genetic Epidemiology, 2015, 39(3):197-206
  • Brenner DR, Brennan P, Boffetta P, Amos C, Spitz M, Chen C, Goodman G, Wichmann E, Bickeboller H, Risch A, McLaughlin JR, Benhamou S, Lewinger JP, Witte JS, Chen G, Bull S, Hung RJ. Hierarchical modeling identifies novel lung cancer susceptibility variants in inflammation pathways among 10,140 cases and 11,012 controls. Humarn Genetics, in pess, 2013.
  • Brenner DR, Boffetta P, Duell EJ, Bickeböller H, Rosenberger A, McCormack V, Muscat JE, Yang P, Wichmann HE, Brueske-Hohlfeld I, Schwartz AG, Cote ML, Tjønneland A, Friis S, Le Marchand L, Zhang ZF, Morgenstern H, Szeszenia-Dabrowska N, Lissowska J, Zaridze D, Rudnai P, Fabianova E, Foretova L, Janout V, Bencko V, Schejbalova M, Brennan P, Mates IN, Lazarus P, Field JK, Raji O, McLaughlin JR, Liu G, Wiencke J, Neri M, Ugolini D, Andrew AS, Lan Q, Hu W, Orlow I, Park BJ, Hung RJ. Previous lung disease and lung cancer risk: a pooled analysis from the international lung cancer consortium. AJE, 2012 176 (7): 573-85
  • Fehringer G, Liu G, Pintilie M, Sykes J, Cheng D, Liu X, Chen Z, Seymour L, Der SD, Shepherd FA, Tsao MS, Hung RJ. Association of the 15q25 and 5p15 lung cancer susceptibility regions with gene expression in lung tumor tissues. CEBP 21(7):1097-104, 2012.
  • Rosenberger A, Bickeböller H, McCormack V, Brenner DR, Duell EJ, Tjønneland A, Friis S, Muscat JE, Yang P, Wichmann HE, Heinrich J, Szeszenia-Dabrowska N, Lissowska J, Zaridze D, Rudnai P, Fabianova E, Janout V, Bencko V, Brennan P, Mates D, Schwartz AG, Cote ML, Zhang ZF, Morgenstern H, Oh SS, Field JK, Raji O, McLaughlin JR, Wiencke J, Lemarchand L, Neri M, Bonassi S, Andrew AS, Lan Q, Hu W, Orlow I, Park BJ, Boffetta P, Hung RJ. Asthma and Lung Cancer Risk: A Systematic Investigation by the International Lung Cancer Consortium. Carcinogenesis 2012, 33(3):587-97.
  • Cote ML, Liu M, Bonassi S, Neri M, Schwartz AG, Christiani DC, Spitz MR, Muscat JE, Rennert G, Andrew AS, Bencko V, Bickeböller H, Boffetta P, Brennan P, Brenner H, Duell EJ, Fabianova E, Field JK, Foretova L, Friis S, Harris CC, Holcatova I, Hong YC, Isla D, Janout V, Kiemeney LA, Kiyohara C, Lan Q, Lazarus P, Lissowska J, Le Marchand L, Mates D, Matsuo K, I. Mayordomo JI, McLaughlin JR, Morgenstern H, Müller H, Orlow I , Park BJ, Raji OY, Rudnai P, Seow A, Stucker I, Szeszenia-Dabrowska N, Teare MD, Tjønnelan A, Ugolini D, van der Heijden HFM, Wichmann E, Wiencke JK, Woll PJ, Yang P, Zaridze D, Zhang ZF, Etzel CJ, Hung RJ. Increased risk of lung cancer in individuals with a family history of the disease: A pooled analysis from the International Lung Cancer Consortium. European Journal of Cancer, 2012 48(13):1957-68.
  • Fehringer G, Liu G, Briollais L, Brennan P, Amos CI, Spitz MR, Bickeböller H, Wichmann HE, Risch A. Hung RJ. Comparison of pathway analysis approaches using lung cancer GWAS data sets. PLoS ONE, 2012, 2012;7(2):e31816.
  • Chu A, Heck JE, Ribeiro KR, Brennan P, Boffetta P, Buffler P, Hung RJ. Wilms tumor: A systematic review and meta–analysis. Pediatric and Perinatal Epidemiology, 2010 Sep;24(5):449-69.
  • Wakefield J, De Vocht F, Hung RJ. Bayesian Mixture Modeling of Gene-Environment and Gene-Gene Interactions. Genetic Epidemiology. Genet Epidemiol. 2010 Jan;34(1):16-25.
  • Hung RJ, Christiani,D.C., Risch,A., Popanda,O., Haugen,A., Zienolddiny,S., Benhamou,S., BOUCHARDY,C., Lan,Q., Spitz,M.R., Wichmann,H.E., Le Marchand,L., Vineis,P., Matullo,G., Kiyohara,C., Zhang,Z.F., Pezeshki,B., Harris,C., Mechanic,L., Seow,A., Ng,D.P.K., Szeszenia-Dabrowska,N., Zaridze,D., Lissowska,J., Rudnai,P., Fabianova,D., Mates,D., Foretova,L., Janout,V., Bencko,V., Caporaso,N., Chen,C., Duell,E.J., Goodman,G., Field,J.K., Houlston,R.S., Hong,Y.C., Landi,M.T., Lazarus,P., Muscat,J., McLaughlin,J., Schwartz,A.G., Shen,H., Stucker,I., Tajima,K., Matsuo,K., Thun,M., Yang,P., Wiencke,J., Andrew,A.S., Monnier,S., Boffetta,P., and Brennan,P. (2007) International Lung Cancer Consortium: Pooled analysis of sequence variants in DNA repair and cell cylce pathways. Cancer Epi.Biomarker Prev., 2008 Nov;17(11):3081-9.
  • Hung RJ, McKay JD, Gaborieau V, Boffetta P, Hashibe M, Zaridze D, Mukeria A, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, Chen C, Goodman G, Field JK, Liloglou T, Xinarianos G, Cassidy A, McLaughlin J, Liu G, Narod S, Krokan HE, Skorpen F, Elvestad MB, Hveem K, Vatten L, Linseisen J, Clavel-Chapelon F, Vineis P, Bueno-de-Mesquita HB, Lund E, Martinez C, Bingham S, Rasmuson T, Hainaut P, Riboli E, Ahrens W, Benhamou S, Lagiou P, Trichopoulos D, Holcátová I, Merletti F, Kjaerheim K, Agudo A, Macfarlane G, Talamini R, Simonato L, Lowry R, Conway DI, Znaor A, Healy C, Zelenika D, Boland A, Delepine M, Foglio M, Lechner D, Matsuda F, Blanche H, Gut I, Heath S, Lathrop M, Brennan P. A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature. 2008 Apr 3;452(7187):633-7
  • Hung RJ, Moore L, Boffetta P, Feng BJ, Toro J, Rothman N, Zaridze D, Navratilova M, Bencko V, Janout V, Kollarova H, Szeszenia-Dabrowska N, Mates D, Chow WH, Brennan P. Family History and the Risk of Kidney Cancer : A Multicenter Case-control Study in Central Europe. CEBP. 2007 Jun;16(6):1287-90.
  • Hung RJ, Hashibe M, McKay J, Gaborieau V, Szeszenia-Dabrowska N, Zaridze D, Lissowska J, Rudnai P, Fabianova E, Mates I, Foretova L, Janout V, Bencko V, Chabrier, Moullan N, Canzian F, Hall J, Boffetta P, Brennan P. Folate related genes and the risk of tobacco-related cancers in Central Europe. Carcinogenesis, 2007, 28(6):1334-40
  • Hung RJ, Baragatti M, Thomas D, McKay J, Szeszenia-Dabrowska N , Zaridze D, Lissowska J, Rudnai P, Fabianova E, Mates D, Foretova L, Janout V, Bencko V, Chabrier A, Moullan N, Canzian F, Hall J, Boffetta P, Brennan P. Inherited Predisposition of Lung Cancer: A Hierarchical Modeling Approach to DNA repair and Cell Cycle Control Pathways. CEBP 2007;16(12):2736–44.
  • Brennan, P., McKay, J., Moore, L., Zaridze, D., Mukeria, A., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Mates, D., Bencko, V., Foretova, L., Janout, V., Chow, W. H., Rothman, N., Chabrier, A., Gaborieau, V., Odefrey, F., Southey, M., Hashibe, M., Hall, J., Boffetta, P., Peto, J., Peto, R., and Hung, RJ. Uncommon CHEK2 mis-sense variant and reduced risk of tobacco-related cancers: case control study. 2007.Hum. Mol. Genet., 16: 1794-1801
  • Hung RJ, Boffetta P, Canzian F, Moullan N, Szeszenia-Dabrowska N, Zaridze D, Lissowska J, Rudnai P, Fabianova E, Mates D, Foretova L, Janout V, Bencko V, Chabrier A, Stefano Landi, Federica Gemignani , Hall J, Brennan P. Sequence variants in cell cycle control pathway, X-ray exposures and lung cancer risk: a multicenter case-control study in Central Europe. Cancer Research, 2006. 66(16):8280-6.
  • Hung RJ, Brennan P, Canzian F, Szeszenia-Dabrowska N, Zaridze D, Lissowska J, Rudnai P, Fabianova E, Mates D, Foretova L, Janout V, Bencko V, Chabrier A, Borel S, Hall J, Boffetta P. Large-Scale Investigation of Base Excision Repair Genetic Polymorphisms and Lung Cancer Risk in a Multicenter Study. JNCI 2005. 97(8): 567-576.
  • Hung RJ, van der Hel O, Tavtigian ST, Bren nan P, Boffetta P, Hashibe M. Perspectives on the Molecular Epidemiology of Aerodigestive Tract Cancers. Mutation Research 2005. 592(1-2):102-18.
  • Hung RJ, Hall J, Brennan P, Boffetta P. Genetic polymorphisms in base excision repair pathways and cancer risk: a HuGE disease association review. American J. Epidemiology 2005. 162(10):925-42.
  • Hung RJ, van der Hel O, Tavtigian ST, Brennan P, Boffetta P, Hashibe M. Perspectives on the Molecular Epidemiology of Aerodigestive Tract Cancers. Mutation Research 2005. 592(1-2):102-18.
  • Hung RJ, Brennan P, Malaveille C, Porru S, Donato F, Boffetta P, Witte JS. Using Hierarchical Modeling in Genetic Association Studies with Multiple Markers: Application to a Case-Control Study on Bladder Cancer. CEBP 2004; 13(6):1013-1021.