John R. McLaughlin PhD
- epidemiology applied to advance population health, to prevent disease and to improve health systems
- integrative population studies to advance knowledge of disease causes and to improve disease prevention
- application of environmental, molecular and genetic epidemiology to improve population health
- disease prevention and control programs that apply existing knowledge to improve health
- collaborative, inter-disciplinary studies that enhance outcomes & capacity for population health research
- studies of environmental factors, genetic factors and their relative contribution to risk
- application of advanced measurement methods in exposure and outcome assessment
- building infrastructure, systems and capacity for chronic disease research and monitoring
- harmonization and collaboration in cancer and chronic disease research across Canada and internationally
- epidemiologic research relevant to populations, individuals, practitioners and policy makers
Specific research areas:
- building platforms for population health research and disease control (e.g., cohort studies, registries)
- identifying and addressing disparities in risk factors and disease patterns
- cancer risk factors, etiology, prevention and screening, including major programs in colorectal cancer, ovarian and related cancers, lung cancer and childhood cancers
- effects of: environmental exposures; hormones; dietary factors; ionizing radiation
- gene-environment interactions: e.g., modification of the effects of exogenous factors by variation in susceptibility; and modification of cancer susceptibility by dietary and other exogenous factors
- epidemiologic methods (cohort and case-control designs; multilevel methods that combine ecological, personal and molecular level exposures; integration of qualitative and quantitative methods; geospatial methods; record linkage; descriptive & analytic methods)
Education & Training History
- Ph.D. (Epidemiology), University of Toronto.
- M.Sc. (Community Health and Epidemiology), Queen’s University.
- B.Sc. (Honours, Life Sciences), Queen’s University.
Primary Teaching Responsibilities
- Introduction to Public Health, 2015
- Research Methods (CHL 5404), 2010-2012.
- Occasional lectures in several courses and departments.
Professional Summary & Appointments
- Chief Science Officer & Senior Scientist, Public Health Ontario, Toronto; 2014-present
- Professor, Dalla Lana School of Public Health; 2007 to present
- Associate Scientist, Occupational Cancer Research Centre, Toronto, 2010 to present
- Senior Scientist & Research Advisor, Public Health Ontario, 2012-2014
- Research Director (Acting), Public Health Ontario Laboratories, 2013-2014
- Senior Investigator, Samuel Lunenfeld Research Institute at Mount Sinai Hospital, Toronto; 1999-2014
- Vice President and Senior Scientist, Cancer Care Ontario, Toronto; 2005–2011.
- Program Leader & Founding Director, Ontario Health Study, Ontario Institute for Cancer Research, Toronto, 2007–2010.
- Founding Director and Leader, Prosserman Centre for Health Research, at the Samuel Lunenfeld Research Institute, Toronto, 2001–2007.
- Head, Henry Rosenberg Program in Epidemiology & Biostatistics, Samuel Lunenfeld Research Institute, Toronto, 1999-2007.
- Associate Professor, Dept of Public Health Sciences, University of Toronto; 1997 until promotion in 2007.
- Research Scientist of the National Cancer Institute of Canada, in the Dept of Public Health Sciences, University of Toronto; 1993-1999.
- Assistant Professor, Dept of Preventive Medicine and Biostatistics, University of Toronto; 1990 until promotion in 1997.
Honours & Awards
- Awarded Fellowship in the Canadian Academy of Health Sciences, 2015.
- Geoffrey R. Howe Distinguished Contributions Award, from the Canadian Society for Epidemiology and Biostatistics for contributions to the field of epidemiology and biostatistics, June 2012.
- Senior Visiting Scientist, Award to visit International Agency for Research on Cancer, Lyon, France; 2011-2012.
- Visiting Scholar, Southern Alberta Cancer Research Institute and Alberta Health Services – Cancer program, Calgary, March 2011.
- Investigator Award, from Canadian Institutes of Health Research; 2000-2005.
- Award for Excellence in Medicine and Health, from the Canadian Cancer Society and the National Cancer Institute of Canada, December 2002.
Current Research Projects
- Population studies to advance disease prevention and health promotion
- 2011-present – Environmental risk factors for cancer modeled using advanced geospatial methods
- 1995-present – Occupational exposures (pesticides, radiation, chemicals) and cancer
- 2005-present – Ontario Health Study: after establishing large-scale, prospective cohort as Founding Director, I continue to support its development and use
- 2000-present – Colorectal Cancer: A population-based, genetic epidemiological research program conducted by an interdisciplinary health research team
- 1995-present – Ovarian Cancer: A province-wide case-control study of the interaction between genetic and reproductive factors in ovarian cancer development and progression1998-present – Lung Cancer: A population-based, case-control study of modifiers of the association between tobacco smoke and lung cancer
Representative papers selected from over 200 peer-reviewed publications:
- McLaughlin JR, Rosen B, Moody J, Pal T, Fan I, Shaw PA, Risch HA, Sellers TA, Sun P, Narod SA. Long-Term Ovarian Cancer Survival Associated With Mutation in BRCA1 or BRCA2. Journal of the National Cancer Institute 2013; Jan 16;105(2):141-8.
- Wild CP, Bucher J, de Jong B, Dillner J, von Gertten C, Groopman JD, Herceg Z, Holmes E, Holmila R, Olsen JH, Ringborg U, Scalbert A, Shibata T, Smith M, Ulrich C, Vineis P, McLaughlin J. Translational cancer research: Balancing prevention and treatment to combat cancer globally. J National Cancer Institute 2015;107(1):353.
- Sun Z, Liu L, Wang PP, Roebothan B, Zhao J, Dicks E, Cotterchio M, Buehler S, Campbell PT, McLaughlin JR, Parfrey PS. Association of total energy intake and macronutrient consumption with colorectal cancer risk: results from a large population-based case-control study in Newfoundland and Labrador and Ontario, Canada. Nutrition Journal 2012;11(1):1-9.
- Uddin M, Thiruvahindrapuram B, Walker S, Wang Z, Hu P, Lamoureux S, Wei J, MacDonald JR, Pellecchia G, Lu C, Lionel AC, Gazzellone M, McLaughlin JR, Brown C, Andrulis I, Knight J, Herbrick J, Wintle RF, Ray P, Stavropoulos DJ, Marshall CR, Scherer SW. A high-resolution copy-number variation resource for clinical and population genetics. Genetics in Medicine 2014 (Dec 11). doi: 10.1038/gim.2014.178.
- Manolio T, Weis B, Cowie C, Hoover R, Hudson K, Kramer B, Perry ME, Berg C, Collins R, Ewart W, Gaziano JM, Hirschfeld S, Johnson C, Marcus P, Masys D, McCarty C, McLaughlin J, Patel A, Peakman T, Pedersen N, Riboli E, Schaefer C, Scott J, Walport M, Collins F. New models for large prospective studies: Is there a better way? American Journal of Epidemiology 2012;175(9):859-66.
- Brenner DR (grad student), Hung RJ, Tsao M, Shepherd F, Johnston M, Narod S, Rubenstein W, McLaughlin JR. Lung cancer risk in never-smokers: A population-based case-control study of epidemiologic risk factors. BMC Cancer 2010; 10(1): 285: 1-9.
- Goode E, et al. (large international consortium including McLaughlin J). A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. Nature Genetics 2010; 42:874-79.
- Hung R et al (large international consoritum including J McLaughlin). A genome-wide association study identifies a susceptibility locus for lung cancer encompassing nicotinic acetylcholine receptor subunit genes on 15q25. Nature 2008; 452:633-7.
- McLaughlin JR, Risch H, Lubinski J, Moller P, Ghadirian P, Lynch H, Karlan B, Fishman D, Rosen B, Neuhausen S, Offit K, Kauff N, Domchek S, Tung N, Friedman E, Foulkes W, Sun P, Narod S and the Hereditary Ovarian Cancer Clinical Study Group. Risk factors for ovarian cancer in carriers of BRCA1 or BRCA2 mutations. Lancet Oncology 2007;8(1):26-34.
- McLaughlin JR, King W, Anderson TW, et al. Paternal radiation exposure and leukaemia in offspring – The Ontario case-control study. British Medical Journal 1993; 307:959-66.