Faculty Member

Wei Xu Ph.D.

Email Address(es)
wxu@uhnres.utoronto.ca
Office Phone
416-946-4497
Office Address
10-511, 610 University Avenue Toronto, Ontario, M5G 2M9
Website(s)
COMBIEL
Division(s)/Office
Biostatistics Division
Position
Associate Professor
SGS Status
Full Member
Appointment Status
Status Only

Research Interests

  • Biostatistics and Bioinformatics
  • Statistical Genetics
  • Cancer Clinical and Translational Research
  • Clinical Trial Design and Analysis
  • Statistical Modeling and Data Mining

Education & Training History

2006 Ph.D. University of Toronto, Biostatistics

2003 M.Sc. Dalhousie University, Statistics

1992 B.Eng. Shanghai Jiao Tong University, Engineering

Other Affiliations

Principal Biostatistician and Scientist,

Princess Margaret Cancer Centre/ Ontario Cancer Institute

Current Research Projects

(2017-2022) Seeking Molecular Signatures for Nasopharyngeal Carcinoma (CIHR)

(2017-2021) Ovarian Cancer Translational Research Initiative (OICR)

(2017-2022) Methodology Development and Implementation for Microbiome Sequencing Data: Hierarchical Modeling on Clustered Taxa Counts with Repeated Measures (NSERC)

(2016-2018) Early detection of tumour response for adaptive therapy in oropharynx cancer (CCSRI)

(2016-2018) X-chromosome wide genetic association on cancer prognostic and pharmacogenetic analysis of clinical trials: methodological development and analysis (CIHR)

Selected Publications (selected from 128 peer-reviewed publications in last five years)

Xu W, Hao M. A unified partial likelihood approach for X-chromosome association on time to event outcomes. Genetic Epidemiology 2017 Nov 26. doi: 10.1002/gepi.22097.

Xu W, Ma J, Greenwood CMT, Paterson AD, Bull SB. Model-Free Linkage Analysis of a Binary Trait. Methods Mol Biol. 2017;1666:343-373.

Korpanty GJ, Eng L, Qiu X, Olusesan Faluyi O, Renouf DJ, Cheng D, Patel D, Chen Z, Tse BC, Knox JJ, Dodbiba L, Teichman J, Azad AK, Wong R, Darling G, Reisman D, Cuffe S, Liu G, Xu W. Association of BRM promoter polymorphisms and esophageal adenocarcinoma outcome. Oncotarget. 2017 Apr 25;8(17):28093-28100.

Xu L, Paterson AD, Xu W. Bayesian Latent Variable Models for Hierarchical Clustered Count Outcomes with Repeated Measures in Microbiome Studies. Genetic Epidemiology 2017 Jan 22. doi: 10.1002/gepi.22031.

Turpin W, Espin-Garcia O, Xu W, Silverberg M, Kevans D, Smith M, Guttman D, Griffiths A, Panancionne R, Otley A, Xu L, Shestopaloff K, Moreno-Hagelsieb G, The GEM Project Research Consortium, Paterson A, Croitoru K. Association of Host Genome with Intestinal Microbial Composition in a Large Healthy Cohort. Nature Genetics 2016 Oct 3. doi: 10.1038/ng.3693.

Xu W, Che J, Kong Q. Recursive Partitioning Method on Competing Risk Outcomes. Cancer Informatics. 2016:Suppl. 2 9-16.

O’Sullivan B, Huang SH, Su J, Garden AS, Sturgis EM, Dahlstrom K, Lee N, Riaz N, Pei X, Koyfman SA, Adelstein D, Burkey BB, Friborg J, Kristensen CA, Gothelf AB, Hoebers F, Kremer B, Speel EJ, Bowles DW, Raben D, Karam SD, Yu E, Xu W. A Proposal for UICC/AJCC Pre-treatment TNM Staging for HPV-related Oropharyngeal Cancer by the International Collaboration on Oropharyngeal Cancer Network for Staging (ICON-S): A Comparative Multi-Centre Cohort Study. Lancet Oncology. 2016 Apr; 17(4):440-51

Azad AK, Bairati I, Qiu X, Girgis H, Cheng L, Waggott D, Cheng D, Mirshams M, Ho J, Fortin A, Vigneault E, Huang SH, O’Sullivan B, Waldron J, Boutros PC, Goldstein D, Meyer F, Xu W*, Liu G*. A Genome-Wide Association Study of Non-HPV-related Head and Neck Squamous Cell Carcinoma Identifies Prognostic Genetic Sequence Variants in the MAP-kinase and Hormone Pathways. Cancer Epidemiology. 2016 May 9;42:173-180.

Xu W, Xu J, Shestopaloff K, Dicks E, Green J, Parfrey P, Green R, Savas S. A genome wide association study on Newfoundland colorectal cancer patients’ survival outcomes. Biomark Res. 2015 Mar 19;3:6

Xu W, Shen XW, Su J, O’Sullivan B, Huang SH. Refining Evaluation Methodology on TNM Stage System: Assessment on HPV-Related Oropharyngeal Cancer. Austin Biometrics and Biostatistics 2015 Volume 2 Issue 1.

Ye P, Zhao X, Sun L, Xu W. A semiparametric additive rates model for multivariate recurrent events with missing event categories. Computational Statistics & Data Analysis. 09/2015; 89.

Xu L, Paterson AD, Turpin W, Xu W. Assessment and Selection of Competing Models for Zero-inflated Microbiome Data. Plos One. 2015 Jul 6;10(7):e0129606.

Huang SH*, Xu W*, Waldron J, Siu L, Shen X, Tong L, Ringash J, Bayley A, Kim J, Hope A, Cho J, Giuliani M, Hansen A, Irish J, Gilbert R, Gullane P, Perez-Ordonez B, Weinreb I, Liu FF, O’Sullivan B. Refining UICC TNM Stage and Prognostic Groups for Non-metastatic HPV-related Oropharyngeal Carcinomas. Journal of Clinical Oncology 2015 Feb 9. pii: Journal of Clinical Oncology.2014.58.6412.

Liu X, Cheng D, Kuang Q, Liu G, Xu W. Association of UGT1A1*28 polymorphisms with irinotecan-induced toxicities in colorectal cancer: a meta-analysis in Caucasians. Pharmacogenomics 2014 Apr;14(2):120-9.

Xu W, Cohen-Woods S, Chen Q, Noor A, Knight J, Hosang G, Parikh SV, De Luca V, Tozzi F, Muglia P, Forte J, McQuillin A, Hu P, Gurling HM, Kennedy JL, McGuffin P, Farmer A, Strauss J, Vincent JB. Genome-wide Association Study of Bipolar Disorder in Canadian and UK Populations corroborates Disease Loci including SYNE1 and CSMD1. BMC Med Genet 2014 Jan 4;15(1):2.

Liu W, Xu W. UGT1A1*28 polymorphisms: a potential pharmacological biomarker of irinotecan-based chemotherapies in colorectal cancer. Pharmacogenomics 2014 15 (9) 1171-1174.

Liu X, Cheng D, Kuang Q, Liu G, Xu W. Association between UGT1A1*28 Polymorphisms and Clinical Outcomes of Irinotecan-Based Chemotherapies in Colorectal Cancer: A Meta-Analysis in Caucasians. PLoS One. 2013;8(3):e58489.

B O’Sullivan, SH Huang, LL. Siu, J Waldron, H Zhao, B Perez-Ordonez, I Weinreb, J Kim, J Ringash, A Bayley, LA Dawson, A Hope, J Cho, J Irish, Ralph Gilbert, P Gullane, A Hui, FF Liu, E Chen, W Xu. De-intensification Candidate Subgroups in HPV-related Oropharyngeal Cancer According to Minimal Risk of Distant Metastasis. JCO 2013 2013 Feb 10;31(5):543-50

Hu P, Muise AM, Xing X, Brumell JH, Silverberg MS, Xu W. Association between a multi-locus genetic risk score and inflammatory bowel disease. Bioinformatics and Biology Insights. 2013 May 19;7:143-52.

Savas S, Liu G, Xu W. Special considerations in prognostic research in cancer involving genetic polymorphisms. BMC Medicine 2013 Jun 17;11(1)

AK Azad, I Bairati, X Qiu, H Huang, D Cheng, A Adjei, G Liu, F Meyer, W Xu. Genetic sequence variants in vitamin D metabolism pathway genes, serum vitamin D level and outcome in head and neck cancer patients. International Journal of Cancer 2013 Jun 1;132(11):2520-7

Muise AM, Xu W, Guo CH, Walters TD, Wolters VM, Fattouh R, Lam GY, Hu P, Murchie R, Sherlock M, Gana JC; NEOPICS, Russell RK, Glogauer M, Duerr RH, Cho JH, Lees CW, Satsangi J, Wilson DC, Paterson AD, Griffiths AM, Silverberg MS, Brumell JH. NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2. Gut. 2012 Jul;61(7):1028-35

Tsao M, Xu W, Sahgal A. A meta-analysis evaluating stereotactic radiosurgery, whole-brain radiotherapy, or both for patients presenting with a limited number of brain metastases. Cancer. 2012 May 1;118(9):2486-93.

Zhao X, Liu Y, Liu L, Xu W. Analysis of Multivariate Recurrent Event Data with Time-dependent Covariates and Informative Censoring. Biometrical Journal 2012 Sep;54(5):585-99