The Biostatistics Seminar Series presents:
“Gene Discovery, Environmental Influence, and Large-effect Interventions for Internalizing Spectrum Disorders” by Dr. Frank Wendt, University of Toronto
Abstract: The internalizing spectrum includes diagnoses of major depressive, generalized anxiety, and post-traumatic stress disorders. These and various trans-diagnostic internalizing traits like neuroticism and suicidality link brain circuitry, behavior, and peripheral biology. The etiologies of internalizing traits also have pronounced influence from biological sex. We will review recent statistical genetics works related to the internalizing spectrum of disorders and traits. Topics of this seminar include novel methodological developments to improve statistical power in GWAS and identify loci with large effect sizes, exploring sex-specific GxE across the genome and trauma-phenome, and using clinical and population cohorts to identify and validate psychological sources of, and non-pharmacological treatment strategies for, internalizing diagnoses.
For Dr. Wendt’s biosketch, please see https://www.dlsph.utoronto.ca/faculty-profile/wendt-frank/ and https://www.utm.utoronto.ca/forensic/people/frank-wendt
All are welcome.