Faculty Member

Malcolm Koo Ph.D.

Email Address(es)
m.koo(at)utoronto.ca
Office Phone
+886 3 8572158 ext 2206
Office Address
Graduate Institute of Long-term Care Tzu Chi University of Science and Technology 880 Chien-kuo Road, section 2. Hualien City ,Hualien, 973302 Taiwan
Division(s)/Office
Social & Behavioural Health Sciences Division
Position
Adjunct Professor

Research Interests

  • Secondary data analysis
  • Complementary and alternative medicine
  • Health survey
  • Systemic autoimmune diseases

Education & Training History

  • Doctor of Philosophy, Epidemiology, Department of Public Health Sciences, University of Toronto, Canada, 2000.
  • Master of Science, Nutritional Sciences, University of Toronto, Canada, 1990.
  • Bachelor of Science, Nutritional Sciences, University of Toronto, Canada, 1987.

Professional Summary & Appointments

  • Adjunct Professor: Dalla Lana School of Public Health, University of Toronto (08/2005 – present)
  • Associate Professor: Graduate Institute of Long-term Care, Tzu Chi University of Science and Technology, Taiwan (8/2018 – present)
  • Research Fellow: Department of Medical Research, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taiwan (11/2012 – 7/2018)
  • Director and Associate Professor: Graduate Institute of Natural Healing Sciences, Nanhua University, Taiwan (8/2005 – 8/2010)
  • Chair and Associate Professor: Department of Natural Biotechnology, Nanhua University, Taiwan (08/2006 – 07/2008)
  • Assistant Professor: Department of Public Health Sciences, University of Toronto (09/2001 – 06/2005)

Current Research Projects

  • Secondary data analysis of the Taiwan’s National Health Insurance Research Database

Representative Publications (2013-present)

  1. Chang RY, Tsai HL, Koo M*, Guo HR* (2020) Association between renal function impairment and multivessel involvement in patients with acute ST-elevation myocardial infarction. Aging doi:10.18632/aging.103299
  2. Tseng CW, Koo M, Hsieh YH* (2020) Cecal intubation time between the use of one- and two-channel water exchange colonoscopy: A randomized controlled trial. Journal of Gastroenterology and Hepatology doi:10.1111/jgh.15043
  3. Hsu CS, Hsu CW, Lu MC*, Koo M* (2020) Risks of ophthalmic disorders in patients with systemic lupus erythematosus – a secondary cohort analysis of population-based claims data. BMC Ophthalmology 20:96. doi:10.1186/s12886-020-01360-w (Koo and Lu are co-corresponding authors)
  4. Hsu CS, Ng KJ, Lu MC*, Koo M* (2020) Predicting the risk of ischemic stroke among patients with rheumatoid arthritis using a simplified RA-CHADSV score based on the CHA2DS2-VASc score. Medicina 56(2):73. doi:10.3390/medicina56020073 (Koo and Lu are co-corresponding authors)
  5. Hsieh YH, Tseng CW, Koo M, Leung FW* (2020) Feasibility of sedation on demand in Taiwan using water exchange and air insufflation: a randomized controlled trial. Journal of Gastroenterology and Hepatology 35(2):256–262. doi:10.1111/jgh.14839
  6. Koo M, Chen HP, Yeh YC* (2020) Coloring activities for anxiety reduction and mood improvement in Taiwanese community-dwelling older adults: A randomized controlled study. BMC Complementary and Alternative Medicine 2020:6964737. doi:10.1155/2020/6964737
  7. Yeh MH, Chiu HP, Wu MC, Koo M, Lin NW, Liao KK, Yeh CC*, Li TM* (2020) Integrated Chinese herbal medicine and Western medicine on the survival in patients with colorectal cancer: A retrospective cohort study. BMC Complementary and Alternative Medicine (Yeh MH, Chiu HP, Wu MC, & Koo M contributed equally to this work). 2020:4561040. doi:10.1155/2020/4561040
  8. Leung FW*, Koo M, Jia H, Leung JW, Cadoni S, Falt P, Hsieh YH, Hu CT, Pan Y, Radaelli F (2020) Water exchange (WE) and quality improvement – enhanced advanced adenoma detection –pooled data analysis of six randomized controlled trials. Journal of Clinical Gastroenterology doi:10.1097/MCG.0000000000001311
  9. Perng SJ, Sung HC*, Chen CJ, Lee TY, Koo M* (2020) Low interest in clinical practicum placement is associated with increased stress in nursing students in Taiwan: A cross-sectional survey study. Nurse Education Today 84:104241. doi:10.1016/j.nedt.2019.104241
  10. Chang RY, Tsai HL, Hsiao PG, Tan CW, Lee CP, Chu IT, Chen YP, Koo M* (2019) Association between heart rate recovery after exercise and renal function in patients referred for treadmill exercise test. PLoS ONE 14(9):e0222236
  11. Hsieh MC, Hsu CW, Lu MC*, Koo M* (2019) Increased risks of psychiatric disorders in patients with primary Sjögren’s syndrome – a secondary cohort analysis of nationwide, population-based health claim data. Clinical Rheumatology 38:3195–3203. doi:10.1007/s10067-019-04705-z (Koo and Lu are co-corresponding authors)
  12. Lu MC, Huang KY, Tung CH, Hsu BB, Wu CH, Koo M*, Lai NS* (2019) Factors associated with disease-specific quality of life in Taiwanese patients with ankylosing spondylitis. BMJ Open 2019;9:e028966. doi:10.1136/bmjopen-2019-028966 (Koo and Lai are co-corresponding authors)
  13. Ng KJ, Huang KY, Tung CH, Hsu BB, Wu CH, Koo M, Hsu CW, Lu MC*, Lai NS* (2019) Modified rheumatoid arthritis impact of disease (RAID) score, a potential tool for depression and anxiety screening for rheumatoid arthritis. Joint, Bone, Spine 86(6):805–807. doi:10.1016/j.jbspin.2019.04.007
  14. Chuang MH, Chuang TL, Koo M*, Wang YF* (2019) Low hemoglobin is associated with low bone mineral density and high risk of bone fracture in male adults: a retrospective medical record review study. American Journal of Men’s Health 13(3):1557988319850378. doi:10.1177/1557988319850378 (Koo & Wang are co-corresponding authors)
  15. Lin TK, You KX, Hsu CT, Li YD, Lin CK, Weng CY*, Koo M* (2019) Negative affectivity and social inhibition are associated with increased cardiac readmission in patients with heart failure: A preliminary observation study. PLoS ONE 14(4):e0215726. doi:10.1371/journal.pone.0215726 (Weng & Koo are co-corresponding authors)
  16. Lin SW, Wang SK, Lu MC, Wang CL*, Koo M* (2019) Acute rhinosinusitis among pediatric patients with allergic rhinitis: A nationwide, population-based cohort study. PLoS ONE 14(2): e0211547. doi:10.1371/journal.pone.0211547 (Wang & Koo are co-corresponding authors)
  17. Yeh MH, Chao CH, Koo M, Chen CY, Yeh CC*, Li TM* (2019) Association of traditional Chinese medicine body constitution and moderate-to-severe cancer-related fatigue in cancer patients. Complementary Therapies in Medicine 43:44–48. doi:10.1016/j.ctim.2019.01.004 (Yeh, Chao, & Koo contributed equally to this work)
  18. Leung FW*, Koo M, Cadoni S, Falt P, Hsieh YH, Amato A, Erriu M, Fojtik P, Gallittu P, Hu CT, Leung JW, Liggi M, Paggi S, Radaelli F, Rondonotti E, Smajstrla Vit, Tseng CW, Urban O (2019) Water exchange produces significantly higher adenoma detection rate than water immersion: Pooled data from two multisite randomized controlled trials. Journal of Clinical Gastroenterology 53(3):201–209. doi:10.1097/MCG.0000000000001012
  19. Jia H, Koo M, Hsieh YH, Tseng CW, Hu CT, Zhang L, Dong T, Pan Y, Leung FW* (2018)  Factors associated with adenoma detection in propofol-sedated patients. Journal of Clinical Gastroenterology 53(7):523–529. doi:10.1097/MCG.0000000000001080
  20. Hsieh YH, Koo M, Tseng CW, Yang HW, Leung FW* (2018) Reduction of multitasking distractions underlies the higher adenoma detection rate of water exchange compared to air insufflation – blinded analysis of withdrawal phase videos. United European Gastroenterology Journal 7(2):230–238. doi:10.1177/2050640618817105 (Koo & Hsieh contributed equally to this work)
  21. Koo M, Lai JT, Yang YK, Liu TC, Hwang JH* (2018) Incidence of vestibular schwannoma in Taiwan from 2001 to 2012: A population-based national health insurance study. Annals of Otology, Rhinology & Laryngology 127(10):694–697. doi:10.1177/0003489418788385
  22. Tseng CW, Koo M, Tseng KC, Hsieh YH* (2018) Meperidine for patients expected to have poor tolerance to esophagogastroduodenoscopy: a double-blind, randomized, controlled study. United European Gastroenterology Journal 6(9):1307–1315. doi:10.1177/2050640618797821
  23. Lin TK, Tu YR, Chen CW, Lin CL, Lin MN, Koo M*, CY Weng* (2018) Blood pressure reactivity and recovery to anger recall in hypertensive patients with type D personality. Acta Cardiologica Sinica 34:417–423. doi:10.6515/ACS.201809_34(5).20180330A (Koo & Weng are co-corresponding authors)
  24. Kao YH, Liu YT, Koo M*, Chiang JK* (2018) Factors associated with emergency services use in Taiwanese advanced cancer patients receiving palliative home care services during out-of-hours periods: A retrospective medical record study. BMC Palliative Care 17(1):46.
  25. Leung FW*, Koo M, Cadoni S, Falt P, Hsieh YH, Amato A, Erriu M, Fojtik P, Gallittu P, Hu CT, Leung JW, Liggi M, Paggi S, Radaelli F, Rondonotti E, Smajstrla Vit, Tseng CW, Urban O (2018) Water exchange produces significantly higher adenoma detection rate than water immersion – pooled data from two multi-site randomized controlled trials. Journal of Clinical Gastroenterology 53(3):201–209. doi:10.1097/MCG.0000000000001012
  26. Cadoni S*, Liggi M, Gallittu P, Mura D, Fuccio L, Koo M, Ishaq S (2018) Underwater endoscopic colorectal polyp resection: feasibility in everyday clinical practice. United European Gastroenterology Journal 6(3):454–462. doi:10.1177/2050640617733923
  27. Koo M, Chen YW* (2017) An exploratory study of diabetes treatment articles on content farm websites. (in Chinese) Bulletin of the Taiwanese Association of Diabetes Educators 13(4):40–46.
  28. Lu MC, Koo M*, Lai NS* (2017) Incident spine surgery in patients with ankylosing spondylitis: a secondary cohort analysis of a nationwide, population-based health claims database. Arthritis Care & Research doi:10.1002/acr.23478. (Koo & Lai are co-corresponding authors)
  29. Lu MC, Tung CH, Wang CL, Huang KY, Koo M*, Lai NS* (2017) Incident osteoarthritis and osteoarthritis-related joint replacement surgery in patients with ankylosing spondylitis: a secondary cohort analysis of a nationwide, population-based health claims database. PLoS One 12(11):e0187594. doi:10.1371/journal.pone.0187594. (Koo & Lai are co-corresponding authors)
  30. Huang YS, Koo M, Chen JC, Hwang JH*. The association between tinnitus and the risk of ischemic cerebrovascular disease in young and middle-aged patients: A secondary case-control analysis of a nationwide, population-based health claims database. PLoS One 12(11):e0187474. doi:10.1371/journal.pone.0187474. (Koo & Huang contributed equally to this work)
  31. Tsai KW, Lin SC, Koo M* (2017) Correlates of depressive symptoms in late middle-aged Taiwanese women: Findings from the 2009 Taiwan National Health Interview Survey. BMC Women’s Health 17(1):103. doi:10.1186/s12905-017-0461-4
  32. Chen JC, Koo M, Hwang JH* (2017) Tinnitus is associated with a higher risk of benign brain tumors: A nationwide, population-based secondary cohort study of young and middle-aged adults. Neuroepidemiology 49(3–4):174–178. doi:10.1159/000481991 (Chen & Koo contributed equally to this work)
  33. Lu MC, Hsu H, Lin CH, Koo M* (2017) Systemic vasculitis is associated with a higher risk of lower extremity amputation in patients with severe peripheral arterial occlusive disease: a secondary analysis of a nationwide, population-based health claims database. Rheumatology International 37(11):1847–1852. doi:10.1007/s00296-017-3828-9
  34. Koo M, Lu MC* (2017) Preparing manuscripts for academic journals from the perspective of peer reviewers.  (in Chinese) Formosan Journal of Medicine 21(6):635–641. doi:6320/FJM.201711_21(6).0011
  35. Tseng CW, Koo M, Hsieh YH* (2017) Cecal intubation time between cap-assisted water exchange and water exchange colonoscopy: A randomized controlled trial. European Journal of Gastroenterology & Hepatology 29(11):1296–1302. doi:10.1097/MEG.0000000000000954
  36. Chiang JK, Lin CW, Wang CL, Koo M*, Kao YH* (2017) Cancer studies based on secondary data analysis of the Taiwan’s National Health Insurance Research Database: A computational text analysis and visualization study. Medicine 94(17):e6704. doi:10.1097/MD.0000000000006704 (Koo & Kao are co-corresponding authors)
  37. Lai NS, Wang CL, Lu MC, Koo M* (2017) Cardiovascular comorbidities of rheumatoid arthritis in Taiwanese adults: a retrospective single center study. Tzu Chi Medical Journal 29(3):171–173. doi:10.4103/tcmj.tcmj_62_17.
  38. Lin HL, Lin MH, Ho CC, Fu CH, Koo M* (2017) Psychometric properties of the Chinese version of the attitudes towards cardiopulmonary resuscitation with defibrillation (ACPRD-C) among female hospital nurses in Taiwan. International Emergency Nursing 33:7–13. doi:10.1016/j.ienj.2017.02.002
  39. Chen KC, Weng CY, Hsiao S, Tsao WL, Koo M* (2017) Cognitive decline and slower reaction time in elderly individuals with mild cognitive impairment. Psychogeriatrics 17(6):364–370. doi:10.1111/psyg.12247
  40. Lu MC, Hsu BB, Koo M*, Lai NS* (2017) Higher risk of incident ankylosing spondylitis in patients with uveitis: a secondary cohort analysis of a nationwide, population-based health claims database. Scandinavian Journal of Rheumatology 46(6):468–473. doi:10.1080/03009742.2017.1282686 (Koo & Lai are co-corresponding authors)
  41. Koo M, Peng CN, Lin SC* (2017) Analysis of the visibility and content of nursing on hospital websites in Taiwan.  (in Chinese) Cheng Ching Medical Journal 13(3):50–57.
  42. Koo M* (2017) Twenty years of clinical trials on aromatherapy research: a bibliometric analysis. Evidence-Based Natural Medicine 2(1):27–58.
  43. Koo M* (2017) A bibliometric analysis of two decades of aromatherapy research. BMC Research Notes 10(1):46. doi:10.1186/s13104-016-2371-1.
  44. Koo M, Tsai KW, Lin SC* (2017) Health effects of fine particulate matter exposure.  (in Chinese) Journal of Medicine and Health 6(1):13–22.
  45. Chen CM, Chen CY, Chen HY, Koo M* (2017) Knowledge of cold syrup and the five core competencies of medication use.  (in Chinese) Journal of Medicine and Health 6(1):61–73.
  46. Wu LF, Yang SH, Koo M* (2017) Psychometric properties of the Chinese version of Spiritual Index of Well-Being in elderly Taiwanese. BMC Geriatrics 17(1):3. doi:10.1186/s12877-016-0392-1
  47. Lai NS, Koo M, Yu CL, Lu MC* (2017) Immunopathogenesis of systemic lupus erythematosus and rheumatoid arthritis: the role of aberrant expression of non-coding RNAs in T cells. Clinical and Experimental Immunology 187(3):327–336. doi:10.1111/cei.12903 (Koo & Lai contributed equally to this work)
  48. Cadoni S, Falt P, Rondonotti E, Radaelli F, Fojtik P, Gallittu P, Liggi M, Amato A, Paggi S, Smajstrla V, Urban O, Erriu M, Koo M, Leung FW* (2017) Water exchange for screening colonoscopy increases adenoma detection rate: a multicenter, double-blinded randomized controlled trial. Endoscopy 49(5):456–467. doi:10.1055/s-0043-101229
  49. Chuang MH, Chuang TL, Koo M, Wang YF* (2017) Trabecular bone score (TBS) reflects trabecular microarchitecture deterioration and fragility fracture in female adult patients receiving glucocorticoid therapy: A pre-post controlled study. BioMed Research International 2017:4210217. doi:10.1155/2017/4210217
  50. Chang JH, Koo M, Wu SW, Chen CY* (2017) Effects of a 12-week program of Tai Chi exercise on the kidney disease quality of life and physical functioning of patients with end-stage renal disease on hemodialysis. Complementary Therapies in Medicine 30:79–83. doi:10.1016/j.ctim.2016.12.002 (Koo & Chang contributed equally to this work)
  51. Hsieh YH*, Tseng CW, Hu CT, Koo M, Leung F (2017) Prospective multicenter randomized controlled trial comparing adenoma detection rate in colonoscopy using water exchange, water immersion and air insufflation. Gastrointestinal Endoscopy 86(1):192–201. doi:10.1016/j.gie.2016.12.005
  52. Lu MC, Juan CY, Koo M*, Lai NS* (2017) Higher incidence of psychiatrist-diagnosed depression in Taiwanese female school-age children and adolescents with type 1 diabetes: a nationwide, population-based retrospective cohort study. Journal of Child and Adolescent Psychopharmacology 27(3):281–284. doi:10.1089/cap.2016.0004 (Koo & Lai are co-corresponding authors)
  53. Hung YT, Lay CJ, Wang CL, Koo M* (2017) Characteristics of nontyphoidal Salmonella gastroenteritis in Taiwanese children: A 9-year period retrospective medical record review. Journal of Infection and Public Health 10(5):518–521. doi:10.1016/j.jiph.2016.09.018
  54. Koo M, Hwang JH* (2017) Risk of tinnitus in patients with sleep apnea: A nationwide, population-based case-control study. Laryngoscope 127(9):2171–2175. doi:10.1002/lary.26323
  55. Koo M, Tsai KW, Lin SC* (2016) Prevention and care of heat emergencies in the elderly.  (in Chinese) Taiwan Geriatrics and Gerontology 11(4):225–236.
  56. Yang CC, Chen CY, Wu CC, Koo M*, Yu ZR, Wang BJ* (2016) Panax ginseng fraction F3 extracted by supercritical carbon dioxide protects against oxidative stress in ARPE-19 cells. International Journal of Molecular Sciences 17(10):1717. doi:10.3390/ijms17101717 (Koo & Wang are co-corresponding authors)
  57. Koo M, Chen JC, Hwang JH* (2016) Risk of peripheral artery occlusive disease in patients with vertigo, tinnitus, or sudden deafness: a secondary case-control analysis of a nationwide, population-based health claims database. PLoS ONE 11(9):e0162629. doi:10.1371/journal.pone.0162629 (Koo & Chen contributed equally to this work)
  58. Yu HC, Lai PH, Lai NS, Huang HB, Koo M, Lu MC* (2016) Increased serum levels of anti-carbamylated 78-kDa glucose-regulated protein antibody in patients with rheumatoid arthritis. International Journal of Molecular Sciences 17:1510. doi:10.3390/ijms17091510
  59. Koo M, Tung CH, Peng CN* (2016) Nursing care management of patients with juvenile idiopathic arthritis. (in Chinese) Journal of Mackay Nursing 10(2):7–15.
  60. Koo M, Lu MC, Lin SC* (2016) Predictors of Internet use for health information among male and female Internet users: Findings from the 2009 Taiwan National Health Interview Survey. International Journal of Medical Informatics 94:155–1 doi:10.1016/j.ijmedinf.2016.07.011 (Koo & Lu contributed equally to this work)
  61. Koo M, Kuo MH* (2016) The opportunities for editing pharmacology articles in Chinese Wikipedia.  (in Chinese) Journal of the Taiwan Pharmacy 32(3):35–39.
  62. Chen PH, Weng YM, Yu ZR, Koo M, Wang BJ* (2016) Extraction temperature affects the activities of antioxidation, carbohydrate-digestion enzymes, and angiotensin-converting enzyme of Pleurotus citrinopileatus Journal of Food and Drug Analysis 24(3):548–555. doi:10.1016/j.jfda.2016.02.005
  63. Lu MC, Chang SC, Huang KY, Koo M*, Lai NS* (2016) Higher risk of thyroid disorders in young patients with type 1 diabetes: A 12-year nationwide, population-based, retrospective cohort study. PLOS ONE 11(3):e0152168. doi:10.1371/journal.pone.0152168 (Koo & Lai are co-corresponding authors)
  64. Koo M, Lai CY* (2016) The pitfalls of academic publishing: predatory journals (in Chinese) Formosan Journal of Medicine 20(2):216–221.
  65. Chien YS, Yu ZR, Koo M*, Wang BJ* (2016) Supercritical fluid extractive fractionation – study of the antioxidant activities of Panax ginseng. Separation Science and Technology 51(6):954–960. doi:10.1080/01496395.2016.1140202 (Koo & Wang are co-corresponding authors)
  66. Lu MC, Yu CL, Yu HC, Huang HB, Koo M, Lai NS* (2016) Anti-citrullinated protein antibodies promote apoptosis of mature human Saos-2 osteoblasts via cell-surface binding to citrullinated heat shock protein 60. Immunobiology 221(1):76–83. doi:10.1016/j.imbio.2015.07.019
  67. Lu MC, Hsieh MC, Koo M*, Lai NS* (2016) Risk of Sjögren’s syndrome in Taiwanese female adults with irregular menstrual cycle: A population-based case control study. Rheumatology International 36(1):155–160. doi:10.1007/s00296-015-3324-z
  68. Wu LF, Koo M* (2016) Randomized controlled trial of a six-week spiritual reminiscence intervention on hope, life satisfaction, and spiritual well-being in elderly with mild and moderate dementia. International Journal of Geriatric Psychiatry 31(2):120–127. doi:10.1002/gps.4300
  69. Koo M, Lin SC* (2016) The image of nursing – a glimpse of the Internet. Japan Journal of Nursing Science 13(4):496–501. doi:10.1111/jjns.12125
  70. Yu IL, Yu ZR, Koo M*, Wang BJ* (2016) A continuous fractionation of ginsenosides and polysaccharides from Panax gingseng using supercritical carbon dioxide technology. Journal of Food Processing and Preservation 40(4):743–748. doi:10.1111/jfpp.12655
  71. Wu LF, Koo M*, Liao YC, Chen YM, Yeh DC (2016) Development and validation of the spiritual care needs inventory for acute care hospital patients in Taiwan. Clinical Nursing Research 25(6):590–606. doi:10.1177/1054773815579609
  72. Chen CY, Wu FJ, Chen CM, Hsu H, Koo M* (2015) Effects of horticultural therapy activity programme for alleviating work-related stress and improving well-being of nursing staff (in Chinese) Journal of the Taiwan Society for Horticultural Science 61(4):281–291.
  73. Lin SC, Tsai KW, Shih HS, Wang SY, Chen MW, Koo M* (2015) Treatment and nursing care of elderly patients with dementia. (in Chinese) Leadership Nursing 16(3):13–19.
  74. Lin MS, Yu ZR, Wang BJ, Wang CC, Weng YM, Koo M* (2015) Bioactive constituent characterization and antioxidant activity of Ganoderma lucidum extract fractionated by supercritical carbon dioxide. Sains Malaysiana 44(12):1685–1691.
  75. Hsueh YC, Wang BJ, Yu ZR, Wang CC, Koo M* (2015) Optimization of a continuous preparation method of Arthrospira (Spirulina) platensis γ-linolenic acid by supercritical carbon dioxide technology using response surface methodology. Sains Malaysiana 44(12):1739–1744.
  76. Ho HC, Koo M, Tsai TH, Chen CY* (2015) Effects of a mindfulness meditation course on learning and cognitive performance among university students in Taiwan. Evidence-Based Complementary and Alternative Medicine 2015:254358. doi:10.1155/2015/254358 (Koo & Ho contributed equally to this work)
  77. Lu MC, Liu KC, Lai NS*, Koo M* (2015) Higher incidence of rheumatoid arthritis in patients with symptomatic osteoarthritis or osteoarthritis-related surgery: a nationwide population-based case-control study in Taiwan. BMJ Open 5:e008513. doi:10.1136/bmjopen-2015-008513 (Koo & Lai are co-corresponding authors)
  78. Huang CH, Lu MC, Koo M* (2015) Dietary patterns of habitual vegetarians – findings from the 2009 National Health Interview Survey  (in Chinese) Nutritional Science Journal 40(3):94–106.
  79. Lu MC, Koo M*, Lai NS* (2015) Clinimetric properties of the Chinese version of the early inflammatory arthritis detection tool. BMC Musculoskeletal Disorders 16:243. doi:10.1186/s12891-015-0706-z
  80. Hsiao IY, Chien CY, Chen CY, Lin TK, Koo M* (2015) Predictors of no improvement in left ventricular ejection fraction among patients with congestive heart failure one year after completing a six-month case management program: a prospective observational study. Tzu Chi Medical Journal 27(4):164–169. doi:10.1016/j.tcmj.2015.07.004
  81. Koo M, Tsai KW, Lin SC* (2015) Evidence-based medicine regarding the nonpharmacological approaches for the alleviation of chronic pain in older adults. (in Chinese) Taiwan Geriatrics and Gerontology 10(2):63–72.
  82. Lai NS, Yu HC, Yu CL, Koo M, Huang HB, Lu MC* (2015) Anti-citrullinated protein antibodies suppress let-7a expression in monocytes from patients with rheumatoid arthritis and facilitate the inflammatory responses in rheumatoid arthritis. Immunobiology 220(12):1351–1358. doi:10.1016/j.imbio.2015.07.007
  83. Lin MC, Yeh YC, Koo M* (2015) Pattern and factors associated with massage therapy and complementary therapies utilization on relieving work-related fatigue among telephone customer services personnel in telecommunications industry.  (in Chinese) Evidence-Based Natural Medicine 1(2):17–26.
  84. Koo M, Peng SM, Chang RY* (2015) Humor therapy is not joking – evidence based research in humor therapy  (in Chinese) Evidence-Based Natural Medicine 1(2):35–47.
  85. Lu MC, Lai CL, Tsai CC, Koo M*, Lai NS* (2015) Increased risk of pulmonary and extrapulmonary tuberculosis in patients with rheumatic diseases. International Journal of Tuberculosis and Lung Disease 19(12):1500–1506. (Koo & Lai are co-corresponding authors)
  86. Koo M, Chen CH, Tsai KW, Lu MC, Lin SC* (2015) Ambulatory medical services utilization for menstrual disorders among female personnel of different medical professions in Taiwan: a nationwide retrospective cohort study. BMC Women’s Health 15:66. doi:10.1186/s12905-015-0220-3
  87. Koo M, Lu MC, Lai CY* (2015) Writing review articles for medical journals. (in Chinese) Formosan Journal of Medicine 19(5):542–549. doi:10.6320/FJM.2015.19(5).13
  88. Lin SC, Tsai KW, Chen MW, Koo M* (2015) Factors associated with health examination utilization among community-dwelling elderly Taiwanese: analysis of the 2009 National Health Interview Survey  (in Chinese) Cheng Ching Medical Journal 11(3):10–21.
  89. Tsai KW, Lin SC, Lu MC, Koo M*(2015). Factors associated with vegetarian dietary habits in Taiwanese adults – analysis of the 2009 National Health Interview Survey  (in Chinese) Journal of Medicine and Health 4(2):41–51.
  90. Wang SY, Liu LC, Lu MC, Koo M* (2015) Comparisons of musculoskeletal disorders among ten different medical professions in Taiwan: A nationwide, population-based study. PLOS ONE 10(4): e0123750. doi:10.1371/journal.pone.0123750
  91. Lai NS, Tsai TY, Koo M, Lu MC* (2015) Increased risk of rheumatoid arthritis in patients with allergic diseases: a nationwide population-based cohort study. Allergy and Asthma Proceedings 36(5):99–103. doi:10.2500/aap.2015.36.3871
  92. Huang CF, Chen CT, Wang PM, Koo M* (2015) Betel-quid, alcohol, and cigarette use were associated with lipid accumulation product among male factory workers in Taiwan. International Health 7(3):218–222. doi:10.1093/inthealth/ihu065
  93. Hsueh YC, Yu ZR, Wang CC, Koo M*, Wang BJ* (2015) Supercritical CO2 extraction of γ-linolenic acid from Spirulina platensis. Applied Mechanics and Materials 764–765: 92-97. doi:10.4028/www.scientific.net/AMM.764-765.92 (Koo & Wang are co-corresponding authors)
  94. Chen JC, Koo M, Hwang JH* (2015) Risks of peripheral arterial occlusive disease in patients with obstructive sleep apnea: a population-based case-control study. Clinical Otolaryngology 40(5):437–442. doi:10.1111/coa.12393 (Koo & Chen contributed equally to this work)
  95. Koo M, Hwang JH* (2015) Risk of sudden sensorineural hearing loss in patients with common preexisting sensorineural hearing impairment: a population-based study in Taiwan. PLOS ONE 10(3): e0121190. doi:10.1371/journal.pone.0121190
  96. Wu LF, Koo M*, Tseng HC, Liao YC, Chen YM (2015) Concordance between nurses’ perception of their ability to provide spiritual care and the identified spiritual needs of hospitalized patients: A cross-sectional observational study. Nursing and Health Sciences 17(4):426–433. doi: 10.1111/nhs.12210
  97. Lin SC, Tsai KW, Chen MW, Koo M* (2015) Prevention and management of geriatric sarcopenia. (in Chinese) Tzu Chi Nursing Journal 14(2):62–68.
  98. Chiang JK, Koo M, Kao YH* (2015) Development of a user-friendly graphic tool to estimate individualized survival curves for advanced cancer patients in hospice care. Supportive Care in Cancer 31(1):29–35. (Kao & Koo contributed equally to this work)
  99. Koo M, Lu MC, Lai CY* (2015) Tabular displays of data in medical journal articles.  (in Chinese) Formosan Journal of Medicine 19(3):311–315. doi:10.6320/FJM.2015.19(3).12
  100. Lu MC, Yin WY, Liu SQ, Koo M, Tung CH, Huang KY, Lai NS* (2015) Increased prevalence of JC polyomavirus viruria was associated with arthritis/arthralgia in patients with systemic lupus erythematosus. Lupus 24(7):687–694. doi:10.1177/0961203314559629 [2014 IF=2.20]
  101. Hsieh YH*, Koo M (2014) Bowel preparation: Is endoscopic administration worth the extra risk? (editorial) Digestive Diseases and Sciences 60(1):1–3. doi:10.1007/s10620-014-3441-7
  102. Lai CY, Lu MC, Koo M* (2014) Analysis of patient-oriented features on the websites of medical centers, regional hospitals, and district hospitals in Taipei City, Taiwan. Journal of Taiwan Association for Medical Informatics 23(3):13–24.
  103. Lee MH, Koo M, Yeh YC* (2014) Factors associated with sleep quality among shiftwork firefighters. (in Chinese) Journal of Occupational Safety and Health (Koo & Lee contributed equally to this work) 22(3):224–234.
  104. Koo M, Liang KL, Jiang RS, Tsao H, Yeh YC* (2014) Association between disease-specific quality of life and complementary medicine use in patients with rhinitis in Taiwan: a cross-sectional survey study. Evidence-Based Complementary and Alternative Medicine 2014:958524. doi:10.1155/2014/958524 (Koo & Liang contributed equally to this work)
  105. Yin WY, Koo M, Lee MC, Lu MC* (2014) Incidence of non-Hodgkin lymphomas and the ten most commonly diagnosed cancers following heart transplantation: a nationwide population-based study in Taiwan. Transplantation (Yin & Koo contributed equally to this work) 98(7):e71–73. doi:10.1097/TP.0000000000000374
  106. Lu MC, Yan ST, Yin WY, Koo M*, Lai NS* (2014) Risk of rheumatoid arthritis in patients with type 2 diabetes: a nationwide population-based case-control study. PLOS ONE 9(7):e101528. doi:10.1371/journal.pone.0101528 (Koo & Lai are co-corresponding authors)
  107. Tsai KW, Lin SC, Koo M* (2014) Factors associated with the uptake of seasonal influenza vaccination among elderly in Taiwan – Analysis of the 2009 National Health Interview Survey. (in Chinese) Taiwan Geriatrics and Gerontology 9(1):28–41.
  108. Lai NS, Tsai TY, Koo M, Huang KY, Tung CH, Lu MC* (2014) Patterns of ambulatory medical care utilization and rheumatologist consultation predating the diagnosis of systemic lupus erythematosus: A national population-based study. PLOS ONE 9(7):e101485. doi:10.1371/journal.pone.0101485
  109. Lu MC, Fa WH, Tsai TY, Koo M*, Lai NS* (2014) Increased utilization of eye disorder-related ambulatory medical services prior to the diagnosis of Sjögren syndrome in female patients. BMJ Open 4(5):e003862. doi:10.1136/bmjopen-2013-003862 (Koo & Lai are co-corresponding authors)
  110. Lin SC, Koo M*, Tsai KW (2014) Association between Helicobacter pylori infection and risk of osteoporosis in elderly Taiwanese women with upper gastrointestinal diseases – a retrospective patient record review. Gastroenterology Research and Practice 2014: 814756. doi:10.1155/2014/814756
  111. Chen MJ, Lin JS, Chen CY*, Koo M* (2014) Association between body constitution of Chinese medicine and acne in male university students. (in Chinese) Journal of Chinese Medicine 25(2):189–203. doi:10.3966/101764462014122502005
  112. Koo M* (2014) Complementary and alternative medicine on Wikipedia: opportunities for improvement. Evidence-Based Complementary and Alternative Medicine 2014:105186. doi:10.1155/2014/105186
  113. Lu MC, Jheng CH, Tsai TY, Koo M*, Lai NS* (2014) Increased dental visits in patients prior to diagnosis of primary Sjögren’s syndrome: a longitudinal population-based study in Taiwan. Rheumatology International 34(11): 1555–1561. doi:10.1007/s00296-014-3003-5. (Koo & Lai are co-corresponding authors)
  114. Hsieh YH, Koo M, Leung FW* (2014) A patient-blinded randomized, controlled trial comparing air insufflation, water immersion and water exchange during minimally sedated colonoscopy. American Journal of Gastroenterology 109(9):1390–1400. doi:10.1038/ajg.2014.126
  115. Chen HM, Tsai MT, Wu R, Koo M* (2014) Outcomes of a visual training program on children with myopia – a pilot study. Evidence-based Natural Medicine 1(1):15–21.
  116. Yang SW, Koo M* (2014) Use of complementary and alternative medicine for the management of HIV/AIDS: a psychoneuroimmunology perspective.](in Chinese) Evidence-based Natural Medicine 1(1):23–36.
  117. Koo M, Lu MC, Tsai TY, Lai CY* (2014) Secondary data analysis: research applications for healthcare providers. (in Chinese) Formosan Journal of Medicine 18(4):471–479. doi:10.6320/FJM.2014.18(4).13
  118. Lu MC, Yin WY, Tsai TY, Koo M*, Lai NS* (2013) Increased risk of primary Sjögren’s syndrome in female patients with thyroid disorders: a longitudinal population-based study in Taiwan. PLOS ONE 8(10): e77210. doi:10.1371/journal.pone.0077210 (Koo & Lai are co-corresponding authors)
  119. Lai NS, Tsai TY, Li CY, Koo M, Yu CL, Lu MC* (2014) Increased frequency and costs of ambulatory medical care utilization prior to the diagnosis of rheumatoid arthritis: a national population-based study. Arthritis Care & Research 66(3):371–378. doi:10.1002/acr.22146
  120. Hsu TK, Koo M, Yeh YC* (2014) Factors associated with the use of complementary medicine in emergency department physicians in Taiwan. (in Chinese) Formosan Journal of Medicine18:153–162. doi:10.6320/FJM.2014.18(2).03 (Koo & Hsu contributed equally to this manuscript)
  121. Hsu TK, Koo M, Yeh YC* (2013) Investigation of factors associated with sleep quality among male emergency department physicians in Taiwan. (in Chinese) Show Chwan Medical Journal 12(1,2):1–9. (Hsu & Koo contributed equally to this manuscript)
  122. Ochirkhuyag U, Koo M, Wu HC*, Yeh YC* (2013) Changes in health status and health services utilization of Mongolian undergraduate and graduate students in Taiwan. Journal of Medicine and Health 2(2):53–62. (Koo & Ochirkhuyag contributed equally to this manuscript)
  123. Koo M, Liang KL, Tsao H, Yen TT, Jiang RS*, Yeh YC* (2013) Factors associated with the use of different treatment modalities among patients with upper airway diseases in Taiwan: a cross-sectional survey study. Journal of Allergy 2013:720879. doi:10.1155/2013/720879
  124. Chiang JK, Kuo TBJ, Fu CH*, Koo M* (2013) Predicting 7-day survival using heart rate variability in hospice patients with non-lung cancers. PLOS ONE 8(7): e69482. doi:10.1371/journal.pone.0069482 (Koo & Fu are co-corresponding authors)
  125. Koo M, Lai NS, Chiang JK* (2013) Short duration of sleep is associated with hyperleptinemia in Taiwanese adults. Journal of Clinical Sleep Medicine 9(10):1049–1055. doi:10.5664/jcsm.3080
  126. Koo M, Lin YC* (2013) A guide to oral presentations in medical and nursing conferences. (in Chinese) Formosan Journal of Medicine 17(5):575–583. doi:10.6320/FJM.2013.17(5).16
  127. Lin SC, Koo M, Chen MW, Tsai KW* (2013) Prevention and care of osteoporosis in the elderly.  (in Chinese) Tzu Chi Nursing Journal 12(4):58–62.
  128. Liang KL, Jiang RS, Wang RC, Koo M, Chen SC, Huang WC, Yeh YC* (2013) Upper-airway inflammation exacerbates bronchial hyperreactivity in mouse models of rhinosinusitis and allergic asthma. International Forum of Allergy & Rhinology 3(7):532–542. doi:10.1002/alr.21160
  129. Chang RY, Koo M*, Lu YC, Lin YF (2013) Effects of habitual Tai Chi exercise on adiponectin, glucose homeostasis, lipid profile, and atherosclerotic burden in individuals with cardiovascular risk factors. Journal of Alternative and Complementary Medicine 19(8):697–703. doi:10.1089/acm.2011.0966
  130. Lin SC, Tsai KW, Chen MW, Koo M* (2013) Association between fatigue and Internet addiction in female hospital nurses. Journal of Advanced Nursing 69(2):374–383. doi:10.1111/j.1365-2648.2012.06016.x