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Faculty Member

Wei Xu Ph.D.

Email Address(es)
wxu(at)uhnres.utoronto.ca
Office Phone
416-946-4497
Office Address
10-511, 610 University Avenue Toronto, Ontario, M5G 2M9
Website(s)
COMBIEL
Division(s)/Institute(s)
Biostatistics Division
Position
Associate Professor
SGS Status
Full Member
Appointment Status
Status Only

Research Interests

  • Biostatistics and Bioinformatics
  • Statistical Genetics
  • Cancer Clinical and Translational Research
  • Clinical Trial Design and Analysis
  • Statistical Modeling and Data Mining
  • Cancer Big Data and AI algorithm

Education & Training History

2006 Ph.D. University of Toronto, Biostatistics

2003 M.Sc. Dalhousie University, Statistics

1992 B.Eng. Shanghai Jiao Tong University, Engineering

Other Affiliations

Clinician Scientist

Princess Margaret Cancer Centre/ Ontario Cancer Institute

Current Research Projects

(2021-2024) Artificial Intelligence, Data Science, and Microbiome Research (PMCF)

(2019-2023) Development of the first pre-operative serum exosomal miRNA test to guide treatment decision in prostate cancer (CIHR)

(2020-2022) Biostatistical and Bioinformatic Longitudinal Analysis of Symptoms and Toxicities in cancer patients (PMCF)

(2017-2022) Methodology Development and Implementation for Microbiome Sequencing Data: Hierarchical Modeling on Clustered Taxa Counts with Repeated Measures (NSERC)

(2017-2022) Seeking Molecular Signatures for Nasopharyngeal Carcinoma (CIHR)

Peer-Reviewed Publications

Selected Publications (selected from 168 peer-reviewed publications in last five years)

Xu W, Huang SH, Su J, Gudi S, O’Sullivan B. Statistical fundamentals on cancer research for clinicians: Working with your statisticians. Clinical Translational Radiation Oncology 27, 75-84, 2021

Shestopaloff K, Dong M, Gao F, Xu W. DCMD: Distance-based classification using mixture distributions on microbiome data. PLoS Comput Biol. 2021 Mar 12;17(3):e1008799.

Dong M, Li L, Chen M, Kusalik A, Xu W. Predictive analysis methods for human microbiome data with application to Parkinson’s disease. PLoS One. 2020 Aug 24;15(8):e0237779.

Espin-Garcia O, Croitoru K, Xu W. Afinite mixture model for X-chromosome association with an emphasis on microbiome data analysis. Genet Epidemiology. 2019 Jan 18.

Shestopaloff K, Escobar MD, Xu W. Analyzing differences between microbiome communities using mixture distributions. Stat Med. 2018 Jul 23. doi: 10.1002/sim.7896.

Chen B, Xu W. Generalized Estimating Equation Modeling on Correlated Microbiome Sequencing Data with Longitudinal Measures. Plos Computational Biology. 2020 Sep 8;16(9):e1008108.

Bai H, Zhong Y, Gao Y, Xu W. Multivariate Mixed Response Model with Pairwise Composite Likelihood Method. Stats 2020, 3(3), 203-220;

Hao M, Zhao X, Xu W. Competing risk modeling and testing for X-chromosome genetic association. Computational Statistics & Data Analysis. Volume 151, November 2020, 107007.

O’Neill AC, Yang D, Roy M, Sebastiampillai S, Hofer SOP, Xu W. Development and Evaluation of a Machine Learning Prediction Model for Flap Failure in Microvascular Breast Reconstruction. Ann Surg Oncol. 2020 Mar 9.

Han D, Hao M, Qu L, Xu W. A Novel Model for the X-chromosome Inactivation Association on Survival Data. Statistical Methods in Medical Research. Stat Methods Med Res. 2019 Jun 30:962280219859037.

Jain R, Xu W. HDSI: High dimensional selection with interactions algorithm on feature selection and testing. PLoS One. 2021 Feb 16;16(2):e0246159. doi: 10.1371/journal.pone.0246159.

Yang D, Xu W. Statistical modeling on human microbiome sequencing data. Big Data and Information Analytics, 2019, 4(1): 1-12. doi: 10.3934/bdia.2019001.

L Xu, AD Paterson, W Xu. Bayesian Latent Variable Models for Hierarchical Clustered Count Outcomes with Repeated Measures in Microbiome Studies. Genetic Epidemiology 2017 Jan 22. doi: 10.1002/gepi.22031.

Xu W, Hao M. A unified partial likelihood approach for X-chromosome association on time to event outcomes. Genetic Epidemiology 2017 Nov 26. doi: 10.1002/gepi.22097.

Xu W, Ma J, Greenwood CMT, Paterson AD, Bull SB. Model-Free Linkage Analysis of a Binary Trait. Methods Mol Biol. 2017;1666:343-373.

Korpanty GJ, Eng L, Qiu X, Olusesan Faluyi O, Renouf DJ, Cheng D, Patel D, Chen Z, Tse BC, Knox JJ, Dodbiba L, Teichman J, Azad AK, Wong R, Darling G, Reisman D, Cuffe S, Liu G, Xu W. Association of BRM promoter polymorphisms and esophageal adenocarcinoma outcome. Oncotarget. 2017 Apr 25;8(17):28093-28100.

Xu L, Paterson AD, Xu W. Bayesian Latent Variable Models for Hierarchical Clustered Count Outcomes with Repeated Measures in Microbiome Studies. Genetic Epidemiology 2017 Jan 22. doi: 10.1002/gepi.22031.

Turpin W, Espin-Garcia O, Xu W, Silverberg M, Kevans D, Smith M, Guttman D, Griffiths A, Panancionne R, Otley A, Xu L, Shestopaloff K, Moreno-Hagelsieb G, The GEM Project Research Consortium, Paterson A, Croitoru K. Association of Host Genome with Intestinal Microbial Composition in a Large Healthy Cohort. Nature Genetics 2016 Oct 3. doi: 10.1038/ng.3693.

Xu W, Che J, Kong Q. Recursive Partitioning Method on Competing Risk Outcomes. Cancer Informatics. 2016:Suppl. 2 9-16.

O’Sullivan B, Huang SH, Su J, Garden AS, Sturgis EM, Dahlstrom K, Lee N, Riaz N, Pei X, Koyfman SA, Adelstein D, Burkey BB, Friborg J, Kristensen CA, Gothelf AB, Hoebers F, Kremer B, Speel EJ, Bowles DW, Raben D, Karam SD, Yu E, Xu W. A Proposal for UICC/AJCC Pre-treatment TNM Staging for HPV-related Oropharyngeal Cancer by the International Collaboration on Oropharyngeal Cancer Network for Staging (ICON-S): A Comparative Multi-Centre Cohort Study. Lancet Oncology. 2016 Apr; 17(4):440-51