Nurses account for half of the global healthcare workforce, providing autonomous and collaborative care for people across the lifespan and care settings. Nurses play critical roles in health promotion, disease prevention, treatment, and rehabilitation, and in the organization, management, and leadership of health systems. Consequently, nurses frequently interact with representatives of the medically-related industry with implications for access to, selection of, and administration of health technologies such as pharmaceuticals and medical devices. Nurses also have unique knowledge and are often witness to the impacts of the activities and practices of commercial entities on health, which can inform effective health promotion and disease prevention. In this seminar, we will discuss the relevance of the commercial determinants of health to global nursing practice and the ways that nurses are uniquely situated to advance work in this field in research and practice toward goals of population health equity.