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Online Event
  • May 3, 2022 from 12:00pm to 1:00pm

Special note: This seminar will be hosted on Zoom. Please register to receive the link and password two hours before the seminar. Please note that space is limited.

In human challenge trials, healthy, typically young, volunteers are exposed to infectious pathogens. They have been used for more than a century to define components of the immune response that correlate with protection. They also help scientists better understand the pathogenesis of disease so that vaccines can be designed to more effectively harness the efficiency of the immune system.

Not all human challenge trials have been ethical by current standards, but the WHO has provided ethical guidance on how the trials can advance vaccine science in a safe manner for participants to improve population health.

In this webinar, we will explore current human challenge trials for SARS-CoV-2 and pertussis. The objectives of the webinar will be to:

1. Understand the utility and challenge of conducting human challenge trials in Canadian and European contexts.
2. Explore the ethical considerations required by investigators and regulators in approving such trials.

This webinar is co-hosted by the University of Toronto’s Centre for Vaccine Preventable Diseases at the Dalla Lana School of Public Health and Canadian Association for Immunization Research, Evaluation and Education​ (CAIRE) near World Immunization Week 2022.

Speaker presentations will be followed by an interactive Q&A session.


– Dr. Shelly Bolotin – Director, Centre for Vaccine Preventable Diseases, Dalla Lana School of Public Health, University of Toronto; Associate Professor, Dalla Lana School of Public Health, University of Toronto; Scientist, Health Protection, Public Health Ontario
– Dr. Manish Sadarangani – Chair, Canadian Association for Immunization Research, Evaluation and Education​ (CAIRE); Associate Professor, Department of Pediatrics, Faculty of Medicine, University of British Columbia; Investigator, BC Children’s Hospital; Director, Vaccine Evaluation Center, BC Children’s Hospital; Sauder Family Chair in Pediatric Infectious Diseases, University of British Columbia


– Dr. Scott Halperin – Professor, Pediatrics, Microbiology, Immunology, Dalhousie University; Director, Canadian Center for Vaccinology; Co-Principal Investigator, Canadian Immunization Monitoring Program–Active (IMPACT); Nominated Principal Investigator, Canadian Immunization Research Network (CIRN)
– Dr. Chris Chiu – Professor of Infectious Diseases, Department of Infectious Disease, Imperial College London

The webinar will take place on Zoom on Tuesday, May 3rd 2022 – You will receive a webinar link and password TWO HOURS before the event.

The webinar will be available on the Dalla Lana School of Public Health’s YouTube page after the livestream concludes.

Questions? Email us at

About the Centre for Vaccine Preventable Diseases, DLSPH, U of T:

With leadership housed at the University of Toronto’s Dalla Lana School of Public Health, we are developing an interdisciplinary group of academic researchers, educators and public health advocates. Our vision is to catalyze cutting-edge research and education that maximizes the health benefits of immunization for everyone.

We aim to contribute locally and globally to healthy communities through excellence in interdisciplinary vaccine-preventable disease and immunization research and education.

About Canadian Association for Immunization Research, Evaluation and Education​ (CAIRE):

CAIRE is a unique professional organization dedicated to building the scientific foundation of optimal immunization programs. CAIRE members are individuals in Canada involved in conducting or supporting vaccine research and immunization program development, evaluation and training.