Title: The mechanistic evidence for carcinogenicity in firefighters and how it contributed to the IARC Group 1 classification for occupational exposure as a firefighter
In June, 2022, international experts met in Lyon, France, to evaluate the evidence for carcinogenicity resulting from the occupational exposure as a firefighter. In this IARC evaluation process, evidence was available from two streams, namely: cancer in humans and mechanistic evidence. The review and evaluation of the mechanistic evidence are structured around the 10 key characteristics of carcinogens. In this talk, I will briefly describe the IARC evaluation process, provide an in-depth overview of the mechanistic evidence for carcinogenicity, and explain how the mechanistic evidence contributed to the overall classification of “carcinogenic to humans” (Group 1).
Presenter: Dr. Alexandra Long
Dr. Alexandra Long completed her PhD in Biology (Specialization: Chemical and Environmental Toxicology) from the University of Ottawa. Her PhD research focused on the genetic toxicity of complex mixtures of polycyclic aromatic hydrocarbons. She completed a NSERC Postdoctoral Fellowship at the University of Toronto in the Department of Pharmacology & Toxicology. Alexandra previously worked for over a decade as a Research Biologist in a Genetic Toxicology lab at Health Canada, and is currently a Scientific Evaluator in the Emerging Approaches Unit of a regulatory bureau within Health Canada. She has participated in two IARC monographs and drinks too much coffee.